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  3. PROTAC CBP/P300 Degrader-1

PROTAC CBP/P300 Degrader-1 

Cat. No.: HY-138536 Purity: 99.18%
Handling Instructions

PROTAC CBP/P300 Degrader-1 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines.

For research use only. We do not sell to patients.

PROTAC CBP/P300 Degrader-1 Chemical Structure

PROTAC CBP/P300 Degrader-1 Chemical Structure

CAS No. : 2484739-48-0

Size Price Stock Quantity
5 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
25 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 5300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 8500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PROTAC CBP/P300 Degrader-1 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTAC CBP/P300 Degrader-1 shows LNCaP prostate cancer cell viability inhibition (IC50=0.4 nM). PROTAC CBP/P300 Degrader-1 (10 nM) induces degradation of P300 (≥ 80%)[1].
PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancel cell lines (IC50s ranging from 0.1-141.4 nM for HEL, NOMO-1, MOLM-13, HL-60, MEG-01, MM.IS, MM.1R, NCL-H929, RPM-8226, AMO-1, WSU-DLCL2, Karpas-422, Pfeiffer, SU-DHL-1, LNCap clone FGC, VCap; 22RV1, NCI-H520, NCI-H703, LK-2, MCE-7, and SK-BR-3 cells)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

893.98

Formula

C₄₆H₅₃F₂N₁₁O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 173.33 mg/mL (193.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1186 mL 5.5930 mL 11.1859 mL
5 mM 0.2237 mL 1.1186 mL 2.2372 mL
10 mM 0.1119 mL 0.5593 mL 1.1186 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 6.5 mg/mL (7.27 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Product Name:
PROTAC CBP/P300 Degrader-1
Cat. No.:
HY-138536
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