PRT3789 epimer

Cat. No.: HY-159607A Purity: 98.83%: Data Sheet
COA

SDS
Handling Instructions
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PRT3789 epimer is an epimer of PRT3789 (HY-159607). PRT3789 is a selective SMARCA2 PROTAC degrader.

For research use only. We do not sell to patients.

PRT3789 epimer Chemical Structure

CAS No. : 3023568-80-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Other Forms of PRT3789 epimer:

PRT3789 In-stock

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Biological Activity
Purity & Documentation
References
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Description

PRT3789 epimer is an epimer of PRT3789 (HY-159607). PRT3789 is a selective SMARCA2 PROTAC degrader^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

891.09

Formula

C₄₇H₅₈N₁₀O₆S

CAS No.

3023568-80-8

Appearance

Solid

Color

White to off-white

SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@@H](C(C)C)C4=CC(O[C@@H](C)CN5CC[C@H](C5)N6CCN7C8=C(NC[C@H]7C6)N=NC(C9=C(C=CC=C9)O)=C8)=NO4)=O)O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (56.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1222 mL	5.6111 mL	11.2222 mL
5 mM	0.2244 mL	1.1222 mL	2.2444 mL
10 mM	0.1122 mL	0.5611 mL	1.1222 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.83%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (253 KB) HNMR (350 KB) LCMS (12966 KB)

Handling Instructions (2659 KB)

References

[1]. Hulse M, et al. PRT3789 Is a First-in-Human SMARCA2-Selective Degrader That Induces Synthetic Lethality in SMARCA4-Mutated Cancers. Cancer Res. 2026;86(1):213-235. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1222 mL	5.6111 mL	11.2222 mL	28.0555 mL
	5 mM	0.2244 mL	1.1222 mL	2.2444 mL	5.6111 mL
	10 mM	0.1122 mL	0.5611 mL	1.1222 mL	2.8056 mL
	15 mM	0.0748 mL	0.3741 mL	0.7481 mL	1.8704 mL
	20 mM	0.0561 mL	0.2806 mL	0.5611 mL	1.4028 mL
	25 mM	0.0449 mL	0.2244 mL	0.4489 mL	1.1222 mL
	30 mM	0.0374 mL	0.1870 mL	0.3741 mL	0.9352 mL
	40 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.7014 mL
	50 mM	0.0224 mL	0.1122 mL	0.2244 mL	0.5611 mL

PRT3789 epimer Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRT3789 epimer3023568-80-8PROTACsPROTACInhibitorinhibitorinhibit

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