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Cat. No.: HY-162411

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E3 ligase Ligand 24

E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC₅₀= 0.053 μM). Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation.

For research use only. We do not sell to patients.

CAS No.: 3038773-47-3
Formula: C₂₁H₂₂Cl₂N₄O₅S
Molecular Weight:513.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

E3 ligase Ligand 24 Chemical Structure

CAS No.: 3038773-47-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Ligands for E3 Ligase Isoforms :

In Vitro

E3 ligase ligand 24 (5μM; 24h) effectively degrades BRD4 protein in HEK293 cells expressing HiBiT-tagged BRD4, and this degradation is not mediated by DCAF15.^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3038773-47-3
Molecular Weight 513.39
Formula C₂₁H₂₂Cl₂N₄O₅S
SMILES

CC1=C(C(N2CCC(C(NC)=O)CC2)=O)OC(S(=O)(NC3=C(NC=C4Cl)C4=C(Cl)C=C3)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lucas SCC, et al. Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. J Med Chem. 2024 Apr 11;67(7):5538-5566. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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E3 ligase Ligand 24

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E3 ligase Ligand 24 Related Classifications

HY-162411 Related Classifications