PROTAC p300 degrader-2
PROTAC MLT Degrader 1 is a heterobifunctional degrader of p300 protein PROTAC based on MLT. PROTAC MLT Degrader 1 significantly reduces the intracellular protein level of p300. PROTAC MLT Degrader 1 can be used in Alzheimer's disease research.
(Pink: p300 ligand (HY-B0075); Blue: Cereblon ligand (HY-41547); Black: linker (HY-140208)).
For research use only. We do not sell to patients.
- Formula: C31H34N6O8
- Molecular Weight:618.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
p300 |
In Vitro
PROTAC p300 degrader-2 (M-PROTAC) (10 μM; 24 h) down-regulates 32 proteins including p300 in Neuro-2a (N2A) cells, with p300 degraded in dose- and time-dependent manners following 10 μM treatment for 24 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 618.64
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Formula C31H34N6O8
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SMILES
O=C(N1C2C(NC(CC2)=O)=O)C3=C(NCCOCCNC(COC4=CC5=C(NC=C5CCNC(C)=O)C=C4)=O)C=CC=C3C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Western Blot
Western blotting (WB) is a commonly used experimental method in molecular biology, biochemistry, and immunogenetics for identifying and quantifying target proteins. It combines gel electrophoresis with immunoassay, enabling researchers to analyze protein expression, post-translational modifications, and molecular weight.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC p300 degrader-2 Related Classifications
HY-179657 Related Classifications
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