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Cat. No.: HY-179657

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PROTAC p300 degrader-2

PROTAC MLT Degrader 1 is a heterobifunctional degrader of p300 protein PROTAC based on MLT. PROTAC MLT Degrader 1 significantly reduces the intracellular protein level of p300. PROTAC MLT Degrader 1 can be used in Alzheimer's disease research.
(Pink: p300 ligand (HY-B0075); Blue: Cereblon ligand (HY-41547); Black: linker (HY-140208)).

For research use only. We do not sell to patients.

Formula: C₃₁H₃₄N₆O₈
Molecular Weight:618.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PROTAC p300 degrader-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC MLT Degrader 1 is a heterobifunctional degrader of p300 protein PROTAC based on MLT. PROTAC MLT Degrader 1 significantly reduces the intracellular protein level of p300. PROTAC MLT Degrader 1 can be used in Alzheimer's disease research^[1]. (Pink: p300 ligand (HY-B0075); Blue: Cereblon ligand (HY-41547); Black: linker (HY-140208)).

IC₅₀ & Target

^[1]

p300

All PROTACs Isoforms :

All Histone Acetyltransferase Isoforms :

In Vitro

PROTAC p300 degrader-2 (M-PROTAC) (10 μM; 24 h) down-regulates 32 proteins including p300 in Neuro-2a (N₂A) cells, with p300 degraded in dose- and time-dependent manners following 10 μM treatment for 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 618.64
Formula C₃₁H₃₄N₆O₈
SMILES

O=C(N1C2C(NC(CC2)=O)=O)C3=C(NCCOCCNC(COC4=CC5=C(NC=C5CCNC(C)=O)C=C4)=O)C=CC=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun Y, et al. AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer-regulated axis. Science advances. 2025 Nov 21;11(47):eadz9283. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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