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Cat. No.: HY-168057

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PROTAC CDK2 Degrader-1

PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader for cyclin-dependent kinase 2 (CDK2). PROTAC CDK2 Degrader-1 inhibits the phosphorylation of RB protein in CDK2 dependent cell line OVCAR3 with an IC₅₀ of 100-500 nM.
(Pink: CDK2 ligand (HY-178084); Blue: Cereblon ligand (HY-178085); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3024971-78-3
Formula: C₃₈H₄₆F₆N₁₂O₄S
Molecular Weight:880.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PROTAC CDK2 Degrader-1 Chemical Structure

CAS No.: 3024971-78-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader for cyclin-dependent kinase 2 (CDK2). PROTAC CDK2 Degrader-1 inhibits the phosphorylation of RB protein in CDK2 dependent cell line OVCAR3 with an IC₅₀ of 100-500 nM^[1]. (Pink: CDK2 ligand (HY-178084); Blue: Cereblon ligand (HY-178085); Black: linker).

All PROTACs Isoforms :

All CDK Isoforms :

Chemical Information

CAS No. 3024971-78-3
Molecular Weight 880.91
Formula C₃₈H₄₆F₆N₁₂O₄S
SMILES

CN1C2=CC(C3CCN(CC4CCN(S(N5CCC(NC6=NC(C7=CN(CC(F)(F)F)N=C7)=C(C(F)(F)F)C=N6)CC5)(=O)=O)CC4)CC3)=CC=C2C(N8CCC(NC8=O)=O)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu Z, et al., Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway. WO2024102849

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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PROTAC CDK2 Degrader-1

All PROTACs Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC CDK2 Degrader-1 Related Classifications

HY-168057 Related Classifications