2. PROTAC Immunology/Inflammation
  3. Ligands for Target Protein for PROTAC IRAK
  4. JH-l-25-NH2

JH-l-25-NH2 is an IRAK1/4 inhibitor analog derived from JH-I-25 and serves as the IRAK4-binding moiety for synthesizing VHL-recruiting and CRBN-recruiting IRAK4 PROTAC degraders.

For research use only. We do not sell to patients.

JH-l-25-NH2

JH-l-25-NH2 Chemical Structure

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JH-l-25-NH2 Related Antibodies

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Description

JH-l-25-NH2 is an IRAK1/4 inhibitor analog derived from JH-I-25 and serves as the IRAK4-binding moiety for synthesizing VHL-recruiting and CRBN-recruiting IRAK4 PROTAC degraders[1].

IC50 & Target[1]

IRAK4

 

Molecular Weight

418.49

Formula

C23H26N6O2
SMILES

O=C(C1=NC(C2=CC=NN2)=CC=C1)NC3=C(OC)C=C(N4CCC5(CNC5)CC4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JH-l-25-NH2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JH-l-25-NH2Ligands for Target Protein for PROTACIRAKTarget Protein-binding MoietyInterleukin-1 receptor associated kinaseIL-1R associated kinaseVHLCRBNPROTAC degradersIRAK1IRAK4Inhibitorinhibitorinhibit

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JH-l-25-NH2
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