1. PROTAC
    Metabolic Enzyme/Protease
  2. PROTACs
    Cytochrome P450
  3. PROTAC CYP1B1 degrader-1

PROTAC CYP1B1 degrader-1 

Cat. No.: HY-146393
Handling Instructions

PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer.

For research use only. We do not sell to patients.

PROTAC CYP1B1 degrader-1 Chemical Structure

PROTAC CYP1B1 degrader-1 Chemical Structure

CAS No. : 2411389-67-6

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Description

PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].

Molecular Weight

785.80

Formula

C43H39N5O10

CAS No.
SMILES

COC1=CC=C(C2=C3OC(C4=CC=C(C=C4)C5=CN(N=N5)CCCCCCOC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=CC(C3=CC(OC)=C12)=O)OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
PROTAC CYP1B1 degrader-1
Cat. No.:
HY-146393
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