1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. PROTAC
    FAK
  3. PROTAC FAK degrader 1

PROTAC FAK degrader 1 

Cat. No.: HY-119932 Purity: 99.91%
Handling Instructions

PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM.

For research use only. We do not sell to patients.

PROTAC FAK degrader 1 Chemical Structure

PROTAC FAK degrader 1 Chemical Structure

CAS No. : 2301916-69-6

Size Price Stock Quantity
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM[1].

IC50 & Target

IC50: 6.5 nM (Focal adhesion kinase)
DC50: 3 nM (Focal adhesion kinase)[1]

Molecular Weight

996.13

Formula

C₄₇H₅₆F₃N₉O₈S₂

CAS No.

2301916-69-6

SMILES

O=C(N[[email protected]](C(N1[[email protected]](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O)C(C)(C)C)CCOCCOC4=CC=C(NC5=NC(NCC6=CC=CC(N(C)S(C)(=O)=O)=C6)=C(C(F)(F)F)C=N5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (200.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0039 mL 5.0194 mL 10.0389 mL
5 mM 0.2008 mL 1.0039 mL 2.0078 mL
10 mM 0.1004 mL 0.5019 mL 1.0039 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (5.02 mM); Suspended solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (5.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC FAK degrader 1PROTAC FAK degrader1PROTAC FAK degrader-1PROTACFAKProteolysis-targeting chimeraPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseInhibitorinhibitorinhibit

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Product name:
PROTAC FAK degrader 1
Cat. No.:
HY-119932
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