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Cat. No.: HY-178118

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PROTAC PDIA1 degrader 1

PROTAC PDIA1 degrader 1 (Compound H4) is a PDIA1 PROTAC degrader with a DC₅₀ of 29.71 μM. PROTAC PDIA1 degrader 1 has potent anticancer activity and significantly inhibits cancer cell proliferation. Pink: PDIA1 ligand (HY-100433); Blue: CRBN ligase ligand (HY-10984); Black: linker (HY-W015088)
(Pink: PDIA1 ligand (HY-100433); Blue: Cereblon ligand (HY-10984); Black: linker (HY-W015088)).

For research use only. We do not sell to patients.

CAS No.: 3024292-21-2
Formula: C₄₀H₄₄N₆O₁₂S
Molecular Weight:832.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PROTAC PDIA1 degrader 1 Chemical Structure

CAS No.: 3024292-21-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC PDIA1 degrader 1 (Compound H4) is a PDIA1 PROTAC degrader with a DC₅₀ of 29.71 μM. PROTAC PDIA1 degrader 1 has potent anticancer activity and significantly inhibits cancer cell proliferation^[1]. Pink: PDIA1 ligand (HY-100433); Blue: CRBN ligase ligand (HY-10984); Black: linker (HY-W015088) (Pink: PDIA1 ligand (HY-100433); Blue: Cereblon ligand (HY-10984); Black: linker (HY-W015088)).

All PROTACs Isoforms :

Chemical Information

CAS No. 3024292-21-2
Molecular Weight 832.88
Formula C₄₀H₄₄N₆O₁₂S
SMILES

COC1=C(N(C(C#C)=O)C(C(NCC(NCCOCCOCCOCCNC2=C(C(N(C3C(NC(CC3)=O)=O)C4=O)=O)C4=CC=C2)=O)=O)C5=CC=CS5)C=CC(OC)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang B, et al. Unveiling a new strategy for PDIA1 inhibition: Integration of activity-based probes profiling and targeted degradation. Bioorg Chem. 2024 Sep;150:107585. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PROTAC PDIA1 degrader 1

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC PDIA1 degrader 1 Related Classifications

HY-178118 Related Classifications