USP7 Ligand-Linker Conjugates 1
Based on 1 Customer Validation
USP7 Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for USP7 (HY-175359) and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358).
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 3098774-65-0
- Formula: C38H49N5O6
- Molecular Weight:671.83
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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USP7 |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3098774-65-0
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Appearance Solid-Liquid Mixture
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Molecular Weight 671.83
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Formula C38H49N5O6
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Color White to off-white
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SMILES
O=C(OC(C)(C)C)CCCCCOC1=CC=C(C2=C(C3=NN2C)N=CN(CC4(O)CCN(C(C[C@@H](C)C5=CC=CC=C5)=O)CC4)C3=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (148.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.4885 mL | 7.4424 mL | 14.8847 mL | 37.2118 mL |
| 5 mM | 0.2977 mL | 1.4885 mL | 2.9769 mL | 7.4424 mL | |
| 10 mM | 0.1488 mL | 0.7442 mL | 1.4885 mL | 3.7212 mL | |
| 15 mM | 0.0992 mL | 0.4962 mL | 0.9923 mL | 2.4808 mL | |
| 20 mM | 0.0744 mL | 0.3721 mL | 0.7442 mL | 1.8606 mL | |
| 25 mM | 0.0595 mL | 0.2977 mL | 0.5954 mL | 1.4885 mL | |
| 30 mM | 0.0496 mL | 0.2481 mL | 0.4962 mL | 1.2404 mL | |
| 40 mM | 0.0372 mL | 0.1861 mL | 0.3721 mL | 0.9303 mL | |
| 50 mM | 0.0298 mL | 0.1488 mL | 0.2977 mL | 0.7442 mL | |
| 60 mM | 0.0248 mL | 0.1240 mL | 0.2481 mL | 0.6202 mL | |
| 80 mM | 0.0186 mL | 0.0930 mL | 0.1861 mL | 0.4651 mL | |
| 100 mM | 0.0149 mL | 0.0744 mL | 0.1488 mL | 0.3721 mL |
USP7 Ligand-Linker Conjugates 1 Related Classifications
HY-175360 Related Classifications
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