2. PROTAC Cell Cycle/DNA Damage
  3. Target Protein Ligand-Linker Conjugates Deubiquitinase
  4. USP7 Ligand-Linker Conjugates 1

USP7 Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for USP7 (HY-175359) and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358).

For research use only. We do not sell to patients.

USP7 Ligand-Linker Conjugates 1

USP7 Ligand-Linker Conjugates 1 Chemical Structure

CAS No. : 3098774-65-0

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Based on 1 publication(s) in Google Scholar

USP7 Ligand-Linker Conjugates 1 Related Antibodies

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Description

USP7 Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for USP7 (HY-175359) and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358)[1].

IC50 & Target[1]

USP7

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

USP7 Ligand-Linker Conjugates 1 Related Antibodies
Molecular Weight

671.83

Formula

C38H49N5O6
CAS No.
Appearance

Solid-Liquid Mixture

Color

White to off-white

SMILES

O=C(OC(C)(C)C)CCCCCOC1=CC=C(C2=C(C3=NN2C)N=CN(CC4(O)CCN(C(C[C@@H](C)C5=CC=CC=C5)=O)CC4)C3=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (148.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4885 mL 7.4424 mL 14.8847 mL
5 mM 0.2977 mL 1.4885 mL 2.9769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4885 mL 7.4424 mL 14.8847 mL 37.2118 mL
5 mM 0.2977 mL 1.4885 mL 2.9769 mL 7.4424 mL
10 mM 0.1488 mL 0.7442 mL 1.4885 mL 3.7212 mL
15 mM 0.0992 mL 0.4962 mL 0.9923 mL 2.4808 mL
20 mM 0.0744 mL 0.3721 mL 0.7442 mL 1.8606 mL
25 mM 0.0595 mL 0.2977 mL 0.5954 mL 1.4885 mL
30 mM 0.0496 mL 0.2481 mL 0.4962 mL 1.2404 mL
40 mM 0.0372 mL 0.1861 mL 0.3721 mL 0.9303 mL
50 mM 0.0298 mL 0.1488 mL 0.2977 mL 0.7442 mL
60 mM 0.0248 mL 0.1240 mL 0.2481 mL 0.6202 mL
80 mM 0.0186 mL 0.0930 mL 0.1861 mL 0.4651 mL
100 mM 0.0149 mL 0.0744 mL 0.1488 mL 0.3721 mL
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USP7 Ligand-Linker Conjugates 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

USP7 Ligand-Linker Conjugates 13098774-65-0Target Protein Ligand-Linker ConjugatesDeubiquitinaseDUBsTarget Protein Ligand-Linker ConjugateUSP7Inhibitorinhibitorinhibit

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