2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs Deubiquitinase
  4. PROTAC USP7 Degrader-1

PROTAC USP7 Degrader-1 is a VHL-recruiting PROTAC and USP7 degrader with binding activity to both USP7 and the VHL E3 ubiquitin ligase. PROTAC USP7 Degrader-1 recruits the VHL E3 ligase to mediate the ubiquitination and subsequent proteolytic degradation of USP7.
(Pink: USP7 ligand (HY-175359); Blue: VHL ligand (HY-112078); Black: linker).

For research use only. We do not sell to patients.

PROTAC USP7 Degrader-1

PROTAC USP7 Degrader-1 Chemical Structure

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PROTAC USP7 Degrader-1 Related Antibodies

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USP1 USP2 USP4 USP7 USP8 USP10 USP21 USP30 UCHL1 USP11 USP15 USP28 USP25

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Description

PROTAC USP7 Degrader-1 is a VHL-recruiting PROTAC and USP7 degrader with binding activity to both USP7 and the VHL E3 ubiquitin ligase. PROTAC USP7 Degrader-1 recruits the VHL E3 ligase to mediate the ubiquitination and subsequent proteolytic degradation of USP7[1]. (Pink: USP7 ligand (HY-175359); Blue: VHL ligand (HY-112078); Black: linker).

IC50 & Target

USP7

25 nM (DC50)

VHL

 

In Vitro

PROTAC USP7 Degrader-1 (compound 40) (0.01-10 μM; 5-24 h) potently degrades USP7 in OCI-AML5 cells with a DC50 of 25 nM, induces significant USP7 degradation in HEK293T_GFP-USP7, MM.1S, HL60, and MOLT4 cells, inhibits OCI-AML5 cell growth, and drives selective downregulation of USP7 and its substrates in MM.1S cells[1].
PROTAC USP7 Degrader-1 (compound 40) (1 μM; 0-60 min) exhibits improved metabolic stability in human liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC USP7 Degrader-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: OCI-AML5, HEK293T_GFP-USP7, MM.1S, HL60, MOLT4
Concentration: 0.01-10 μM; 0.1 μM; 1 μM
Incubation Time: 5 h; 24 h
Result: Induced 81% USP7 degradation in OCI-AML5 cells at 0.1 μM for 24 h.
Induced 38% USP7 degradation in HEK293T_GFP-USP7 cells at 0.1 μM for 24 h.
Induced 23% cell growth inhibition in OCI-AML5 cells at 0.1 μM for 24 h.
Exhibited a DC50 of 25 nM and a Dₘₐₓ of 95% for USP7 degradation in OCI-AML5 cells after 24 h treatment.
Induced significant USP7 degradation in MM.1S, HL60, and MOLT4 cells at 1 μM for 24 h.
Caused significant downregulation of USP7 and known USP7 substrates including FBXO38, TRIM27, and RNF220 in MM.1S cells at 1 μM for 5 h, with a cleaner degradation fingerprint compared to a reference compound.
Molecular Weight

1183.51

Formula

C64H86N12O8S
SMILES

O=C([C@H]1N(C([C@@H](NC(CCCCCOC2=CC=C(C3=C(C4=NN3C)N=CN(CC5(O)CCN(C(C[C@@H](C)C6=CC=CC=C6)=O)CC5)C4=O)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C7=CC=C(C8=C(N9CCN(CCN(C)C)CC9)N=CS8)C=C7)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC USP7 Degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC USP7 Degrader-1PROTACsDeubiquitinaseDUBshuman liver microsomesHEK293T_GFP-USP7 cellsHL60 cellsMM.1S cellsMOLT4 cellsVHL E3 ubiquitin ligaseOCI-AML5 cellsUSP7proteolytic degradationubiquitinationInhibitorinhibitorinhibit

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