PROTAC HBeAg degrader-1
PROTAC HBeAg degrader-1 is a PROTAC targeting degradation agent for HBeAg. PROTAC HBeAg degrader-1 recruits the VHL E3 ligase but degrades HBV protein HBeAg through VHL-independent mechanism. PROTAC HBeAg degrader-1 decreases levels of secreted and intracellular HBeAg. PROTAC HBeAg degrader-1 can be used for the research of hepatitis B virus (HBV).
(Pink: HBeAg ligand (HY-174857); Blue: VHL ligand (HY-125845); Black: linker).
For research use only. We do not sell to patients.
- Formula: C48H57ClFN9O7S2
- Molecular Weight:990.60
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
|
VHL |
PROTAC HBeAg degrader-1 (Compound LH-3) (0.1-100 μM, 24 h) decreases levels of secreted and intracellular HBeAg in a concentration dependent manner in HEK293THiBiT-HBeAg-S cells[1].
PROTAC HBeAg degrader-1 (10 μM, 24 h) shows VHL-dependent depletion of HBeAg, rather than VHL recruitment in HEK293THiBiT-HBeAg-S cells[1].
PROTAC HBeAg degrader-1 (10 μM, 6 days) causes a strong reduction in HBcAg in HepAD38 cells[1].
PROTAC HBeAg degrader-1 (10 μM, 24 h) is effective at curtailing T109I HBV produced WT HBeAg in Huh7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HEK293T, HEK293TVHL KO cells
-
Concentration:10 μM
-
Incubation Time:24 h
-
Result:Showed statistically significant, albeit minor, rescue of secreted HBeAg levels in HEK293TVHL KO cells.
-
Cell Line:HepAD38 cells
-
Concentration:10 μM
-
Incubation Time:6 days
-
Result:Caused a strong reduction in HBcAg.
Chemical Information
-
Molecular Weight 990.60
-
Formula C48H57ClFN9O7S2
-
SMILES
O=C(C1=C(CN2CCN(C(CCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6=NC=CS6)=N[C@H]1C7=CC=C(F)C=C7Cl)OC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC HBeAg degrader-1 Related Classifications
HY-174856 Related Classifications
Powered by Bioz