country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-179467

Copy Link Print Information

PROTAC hCAII degrader-1

PROTAC hCAII degrader-1 is a potent PROTAC human carbonic anhydrase II (hCAII) degrader with an DC₅₀ of 0.5 nM in HEK293 cells. PROTAC hCAII degrader-1 recruits cereblon (CRBN) E3 ubiquitin ligase to form a ternary complex. PROTAC hCAII degrader-1 enables ubiquitination and subsequent proteasomal degradation of hCAII.
(Pink: CA Ⅱ ligand (HY-B0989); Blue: Cereblon ligand (HY-41547); Black: linker (HY-133388)).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2892306-56-6
Formule: C₃₂H₄₁N₅O₇S
Masse moléculaire:639.76

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PROTAC hCAII degrader-1 Chemical Structure

CAS No.: 2892306-56-6

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PROTAC hCAII degrader-1 is a potent PROTAC human carbonic anhydrase II (hCAII) degrader with an DC₅₀ of 0.5 nM in HEK293 cells. PROTAC hCAII degrader-1 recruits cereblon (CRBN) E3 ubiquitin ligase to form a ternary complex. PROTAC hCAII degrader-1 enables ubiquitination and subsequent proteasomal degradation of hCAII^[1]. (Pink: CA Ⅱ ligand (HY-B0989); Blue: Cereblon ligand (HY-41547); Black: linker (HY-133388)).

IC₅₀ & Target^[1]

hCA II

0.5 nM (DC₅₀)

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform Carbonic Anhydrase :

In Vitro

PROTAC hCAII degrader-1 (compound Degrader 11) (5 pM-15 μM; 0-48 h) potently degrades hCAII in HEK293 cells with a DC₅₀ of 0.5 nM, D_Max of 100%, and sustained activity over 48 h^[1].
PROTAC hCAII degrader-1 (50 nM; 6 h) blocks hCAII degradation when co-treated with Lenalidomide (HY-A0003), Acetazolamide (HY-B0782), or MG132 (HY-13259) in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293 cells
Concentration:

0.005, 0.05, 0.5, 5, 50, 500, 5000, 10000, 15000 nM
Incubation Time:

0, 2, 6, 12, 24, 48 h
Result:

Resulted in degradation of hCAII at concentrations as low as 50 pM, with near-complete degradation at 5 nM.
Showed no 'hook effect' at concentrations up to 15 μM.
Showed hCAII depletion beginning within 2 h, reaching maximal effect by 6 h, and sustaining degradation for 48 h.

Chemical Information

CAS No. 2892306-56-6
Masse moléculaire 639.76
Formule C₃₂H₄₁N₅O₇S
SMILES

O=C(C1=CC=C(S(=O)(N)=O)C=C1)NCCCCCCCCCCCCNC2=CC=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C2C3=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. O'Herin CB, et al. Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J Med Chem. 2023;66(4):2789-2803. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

PROTAC hCAII degrader-1

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform Carbonic Anhydrase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PROTAC hCAII degrader-1 Related Classifications

HY-179467 Related Classifications