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Cat. No.: HY-180901

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BRD3 ligand-1

BRD3 ligand-1 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC BRD3 degrader-1 (HY-180889).

For research use only. We do not sell to patients.

CAS No.: 2257497-24-6
Formula: C₂₅H₂₃N₃O₅S
Molecular Weight:477.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BRD3 ligand-1 Chemical Structure

CAS No.: 2257497-24-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

BRD3 ligand-1 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC BRD3 degrader-1 (HY-180889)^[1].

IC₅₀ & Target^[1]

BRD3

All Epigenetic Reader Domain Isoforms :

Chemical Information

CAS No. 2257497-24-6
Molecular Weight 477.53
Formula C₂₅H₂₃N₃O₅S
SMILES

CCS(=O)(NC1=CC=C(OC2=CC(OCC#C)=CC=C2)C(C3=CN(C)C(C4=C3C=CN4)=O)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Z, et al. BRD3 PROTAC Degrader Targets H3K18ac to Alleviate Retinal Microglia-Driven Uveitis. iScience. 2025 Dec 22:114526.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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