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Cat. No.: HY-183251

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PROTAC p300 degrader-1

PROTAC p300 degrader-1 is a paralog-selective, PROTAC-based degrader targeting the p300/CBP protein. It exhibits potent antiproliferative, cell cycle arrest and pro-apoptotic activities, and can be used in the research and development of antitumor drugs and related mechanism studies for hematological malignancies (AML, MM, NHL).

For research use only. We do not sell to patients.

Formula: C₅₀H₅₈F₂N₁₀O₅
Molecular Weight:917.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC p300 degrader-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

All Histone Acetyltransferase Isoforms :

In Vitro

PROTAC p300 degrader-1 (Compound 27) selectively degrades p300 protein and induces potent anti-tumor cell proliferation activity in in vitro cell experiments^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 917.06
Formula C₅₀H₅₈F₂N₁₀O₅
SMILES

O=C(N(CC1)C2=CC(CC[C@@H]3CC[C@@H](NC(CN4C=C(C5=CC(CCCN6C7=NN(C8CCOCC8)C9=C7CN(C(NC)=O)CC9)=C6C=C5C(F)F)C=N4)=O)CC3)=CC%10=C2C=CC=C%10)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Song M, et al. Inhibition of de novo purine biosynthesis via PPAT targeting by cucurbitacin B restrains esophageal squamous cell carcinoma growth[J]. Cancer Research, 2026, 86(7_Supplement): 3042-3042.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC p300 degrader-1

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

All Histone Acetyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC p300 degrader-1 Related Classifications

HY-183251 Related Classifications