PROTAC p300 degrader-1

Cat. No.: HY-183251: Data Sheet Handling Instructions
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PROTAC p300 degrader-1 is a paralog-selective, PROTAC-based degrader targeting the p300/CBP protein. It exhibits potent antiproliferative, cell cycle arrest and pro-apoptotic activities, and can be used in the research and development of antitumor drugs and related mechanism studies for hematological malignancies (AML, MM, NHL).

For research use only. We do not sell to patients.

PROTAC p300 degrader-1 Chemical Structure

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Description	PROTAC p300 degrader-1 is a paralog-selective, PROTAC-based degrader targeting the p300/CBP protein. It exhibits potent antiproliferative, cell cycle arrest and pro-apoptotic activities, and can be used in the research and development of antitumor drugs and related mechanism studies for hematological malignancies (AML, MM, NHL)^[1].
In Vitro	PROTAC p300 degrader-1 (Compound 27) selectively degrades p300 protein and induces potent anti-tumor cell proliferation activity in in vitro cell experiments^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. PROTAC p300 degrader-1 Related Antibodies
Molecular Weight	917.06
Formula	C₅₀H₅₈F₂N₁₀O₅
SMILES	O=C(N(CC1)C2=CC(CC[C@@H]3CC[C@@H](NC(CN4C=C(C5=CC(CCCN6C7=NN(C8CCOCC8)C9=C7CN(C(NC)=O)CC9)=C6C=C5C(F)F)C=N4)=O)CC3)=CC%10=C2C=CC=C%10)NC1=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Asem M S, et al. Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies[J]. Nature Communications, 2026.