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Cat. No.: HY-160262

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PROTAC AR/BET protein degrader-1

PROTAC AR/BET protein degrader-1 (Compound 149) is an Androgen Receptor and BET (bromodomain and extra-terminal domain) protein degrader that can be used in cancer research.
(Pink: Androgen Receptor and BET ligand (HY-175790); Blue: Cereblon ligand (HY-W023573); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2571123-81-2
Formula: C₄₃H₄₄N₆O₅
Molecular Weight:724.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PROTAC AR/BET protein degrader-1 Chemical Structure

CAS No.: 2571123-81-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC AR/BET protein degrader-1 (Compound 149) is an Androgen Receptor and BET (bromodomain and extra-terminal domain) protein degrader that can be used in cancer research^[1]. (Pink: Androgen Receptor and BET ligand (HY-175790); Blue: Cereblon ligand (HY-W023573); Black: linker).

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Chemical Information

CAS No. 2571123-81-2
Molecular Weight 724.85
Formula C₄₃H₄₄N₆O₅
SMILES

CC1=NOC(C)=C1C2=CC=C(C)C(N(C[C@@H]3CC[C@@H](CNC4=CC(C(N(C5CCC(NC5=O)=O)C6=O)=O)=C6C=C4)CC3)C7=CC=C(C8(C#N)CC8)C=C7)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lyu Haibin, et al. Aromatic Amine Ar and Bet Targeted Protein Degradation Chimeric Compound and Application Thereof. CN-111944012-A

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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PROTAC AR/BET protein degrader-1

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