PROTAC BRM degrader-1
PROTAC BRM degrader-1 (compound 17) is a PROTAC-based BRM and BRG1 degrader, with DC50 values of 93 pM and 4.9 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2378051-80-8
- Formula: C57H69N11O8S
- Molecular Weight:1068.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTAC BRM degrader-1 (compound 17)[1] DC50：93 pM (BRM), 4.9 nM (BRG1)[1]
Chemical Information
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CAS No. 2378051-80-8
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Molecular Weight 1068.29
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Formula C57H69N11O8S
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SMILES
NC1=C(C=C(C(C=CC=C2)=C2O)N=N1)N3C[C@H](CC4)N(C5=CC=NC(O[C@@H](C6)C[C@H]6OC(CC7)CCN7CCOC8=NOC([C@@H](C(C)C)C(N(C[C@@H]9O)[C@@H](C9)C(N[C@H](C%10=CC=C(C(SC=N%11)=C%11C)C=C%10)C)=O)=O)=C8)=C5)[C@H]4C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Berlin M, et al. PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models. J Med Chem. 2024 Jan 5. [Content Brief]
[2]. Cantley J, Ye X, Rousseau E, et al. Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers. Nat Commun. 2022;13(1):6814. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC BRM degrader-1 Related Classifications
HY-163152 Related Classifications
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