2378051-80-8
2378051-80-8
Chemical Structure
PROTAC BRM degrader-1
- CAS No.: 2378051-80-8
- Formula:C57H69N11O8S
- Molecular Weight:1068.29
InChIKey: MOMWKZXTQZEWBK-YZJDURMXSA-N
SMILES: NC1=C(C=C(C(C=CC=C2)=C2O)N=N1)N3C[C@H](CC4)N(C5=CC=NC(O[C@@H](C6)C[C@H]6OC(CC7)CCN7CCOC8=NOC([C@@H](C(C)C)C(N(C[C@@H]9O)[C@@H](C9)C(N[C@H](C%10=CC=C(C(SC=N%11)=C%11C)C=C%10)C)=O)=O)=C8)=C5)[C@H]4C3
Biological Activity: PROTAC BRM degrader-1 (compound 17) is a PROTAC-based BRM and BRG1 degrader, with DC50 values of 93 pM and 4.9 nM, respectively[1].
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PROTAC BRM degrader-1 | PROTAC BRM degrader-1 (compound 17) is a PROTAC-based BRM and BRG1 degrader, with DC50 values of 93 pM and 4.9 nM, respectively. | |||||||||||||||||||||
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References
Keywords
