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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
891 Results for "
Cell-Surface
" in MedChemExpress (MCE) Product Catalog:
Products (891)
891 Results for "Cell-Surface" in MCE Product Catalog:
51
51 Publications Verification
Synonyms: VX-445
Research Areas:
Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .
48
48 Cited Publications
Target:
Research Areas:
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
32
32 Cited Publications
Cat. No.: HY-P0023
CAS No.: 161552-03-0
32
32 Cited Publications
Cat. No.: HY-P0023A
CAS No.: 500577-51-5
28
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .
23
Category:
Polysaccharides Neurological Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides
Target:
21
Target:
21
Category:
Zea mays L. Moisture Plants Endogenous metabolite Human Gut Microbiota Metabolites Polysaccharides Gramineae Cosmetic Research Disease Research Fields Saccharides Cancer
Target:
15
15 Cited Publications
Target:
Research Areas:
11
11 Cited Publications
Cat. No.: HY-D0986
CAS No.: 115534-33-3
10
10 Cited Publications
Synonyms: TIC10; ONC-201
Target:
Research Areas:
Dordaviprone (TIC10) is a potent, orally active, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. Dordaviprone can cross the blood-brain barrier .
9
Target:
Research Areas:
7
7 Cited Publications
5
Target:
4
4 Cited Publications
Cat. No.: HY-P7696
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MUC16; FLJ14303; Mucin 16, Cell Surface Associated; Mucin-16; CA125; CA125 Ovarian Cancer Antigen; CA-125; Mucin-16 Short Isoform; Ovarian Cancer-Related Tumor Marker CA125; Mucin-16 Long Isoform; Ovarian Carcinoma Antigen CA125; MUC-16; Cancer Antigen 12
Species:
Human
Source:
HEK293
3
Target:
Research Areas:
3
3 Cited Publications
Cat. No.: HY-P99126
Target:
Research Areas:
2
2 Cited Publications
Synonyms: PD-1/PD-L1-IN-8
Target:
Research Areas:
INCB086550 is a potent, oral, small-molecule PD-L1 inhibitor with IC50s value of 3.1, 4.9 and 1.9 nM for human, cynomolgus, and rat, respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research .
2
2 Cited Publications
Cat. No.: HY-P9981
CAS No.: 1422527-84-1
Synonyms: XmAb5574; MOR00208; Tafasitamab-cxix; MOR-208
Target:
Research Areas:
2
2 Cited Publications
Cat. No.: HY-P99011
CAS No.: 1855925-27-7
Synonyms: RG-7802; RO-6958688; CEA-TCB
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
