2. Metabolic Enzyme/Protease
  3. Lipase
  4. H-Pro-Glu-OH

H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway.

For research use only. We do not sell to patients.

H-Pro-Glu-OH

H-Pro-Glu-OH Chemical Structure

CAS No. : 67644-00-2

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Based on 1 publication(s) in Google Scholar

H-Pro-Glu-OH Related Antibodies

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Description

H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway[1].

Cellular Effect
Cell Line Type Value Description References
MDCK EC50
> 5 mM
Compound: 59
Activation of human PEPT1 expressed in MDCK cells
Activation of human PEPT1 expressed in MDCK cells
[PMID: 16759105]
MDCK IC50
12.3 mM
Compound: 59
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
[PMID: 16759105]
Molecular Weight

244.24

Formula

C10H16N2O5
CAS No.
SMILES

O=C(CC[C@H](NC([C@H]1NCCC1)=O)C(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (20.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0943 mL 20.4717 mL 40.9433 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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In Vivo Dissolution Calculator
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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0943 mL 20.4717 mL 40.9433 mL 102.3583 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL 20.4717 mL
10 mM 0.4094 mL 2.0472 mL 4.0943 mL 10.2358 mL
15 mM 0.2730 mL 1.3648 mL 2.7296 mL 6.8239 mL
20 mM 0.2047 mL 1.0236 mL 2.0472 mL 5.1179 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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H-Pro-Glu-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Pro-Glu-OH67644-00-2LipasePro-GluPELipY LipasesPathogenic MycobacteriaESX-5 PathwayInhibitorinhibitorinhibit

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H-Pro-Glu-OH
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HY-118481
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