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  5. CD2 Protein, Human (HEK293, Fc)

CD2 Protein, Human (HEK293, Fc)

Cat. No.: HY-P72886
Handling Instructions

CD2 Protein, a cell surface glycoprotein, plays a crucial role in T-cell activation and adhesion. It interacts with its ligand, CD58, facilitating immune responses and cell-to-cell communication. CD2 Protein is also a potential target for immunotherapy and may contribute to the development of novel treatments for immune-related disorders. CD2 Protein, Human (HEK293, Fc) is the recombinant human-derived CD2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD2 Protein, Human (HEK293, Fc) is 185 a.a., with molecular weight of ~48 kDa.

For research use only. We do not sell to patients.

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Description

CD2 Protein, a cell surface glycoprotein, plays a crucial role in T-cell activation and adhesion. It interacts with its ligand, CD58, facilitating immune responses and cell-to-cell communication. CD2 Protein is also a potential target for immunotherapy and may contribute to the development of novel treatments for immune-related disorders. CD2 Protein, Human (HEK293, Fc) is the recombinant human-derived CD2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD2 Protein, Human (HEK293, Fc) is 185 a.a., with molecular weight of ~48 kDa.

Background

The CD2 protein plays a pivotal role in mediating adhesion between T-cells and other cell types by interacting with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1. Beyond its adhesive function, CD2 is implicated in triggering T-cells, with its cytoplasmic domain serving a crucial role in signaling. CD2 also interacts with CD48 and CD58 (LFA-3), underscoring its involvement in cellular interactions. Additionally, CD2 engages with CD2AP and PSTPIP1, suggesting its versatility in cellular signaling pathways. Notably, the interaction between CD2 and FCGR3A modulates NK cell activation and cytotoxicity, highlighting the diverse roles of CD2 in immune cell functions.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

P06729 (K25-D209)

Gene ID

914  [NCBI]

Molecular Construction
N-term
CD2 (K25-D209)
Accession # P06729
hFc
C-term
Synonyms
T-cell surface antigen CD2; LFA-3 receptor; LFA-2; CD2; SRBC
AA Sequence

MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLD

Molecular Weight

Approximately 48 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CD2 Protein, Human (HEK293, Fc)
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HY-P72886
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