CD2 Protein, Human (HEK293, Fc)

CD2 Protein, a cell surface glycoprotein, plays a crucial role in T-cell activation and adhesion. It interacts with its ligand, CD58, facilitating immune responses and cell-to-cell communication. CD2 Protein is also a potential target for immunotherapy and may contribute to the development of novel treatments for immune-related disorders. CD2 Protein, Human (HEK293, Fc) is the recombinant human-derived CD2 protein, expressed by HEK293 , with C-hFc labeled tag.

The CD2 protein plays a pivotal role in mediating adhesion between T-cells and other cell types by interacting with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1. Beyond its adhesive function, CD2 is implicated in triggering T-cells, with its cytoplasmic domain serving a crucial role in signaling. CD2 also interacts with CD48 and CD58 (LFA-3), underscoring its involvement in cellular interactions. Additionally, CD2 engages with CD2AP and PSTPIP1, suggesting its versatility in cellular signaling pathways. Notably, the interaction between CD2 and FCGR3A modulates NK cell activation and cytotoxicity, highlighting the diverse roles of CD2 in immune cell functions.

Immobilized human CD58-His at 2 μg/mL (100 μL/well) can bind human CD2-Fc, the EC₅₀ of human CD2-Fc is 14.1ng/mL.

Human

HEK293

C-hFc

P06729 (K25-D209)

914  [NCBI]

Extracellular Domain

MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLD

≥ 90%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.