CD2 Protein, Human (HEK293, Fc)
Based on 1 Customer Validation
CD2 Protein, a cell surface glycoprotein, plays a crucial role in T-cell activation and adhesion. It interacts with its ligand, CD58, facilitating immune responses and cell-to-cell communication. CD2 Protein is also a potential target for immunotherapy and may contribute to the development of novel treatments for immune-related disorders. CD2 Protein, Human (HEK293, Fc) is the recombinant human-derived CD2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CD2 Protein, a cell surface glycoprotein, plays a crucial role in T-cell activation and adhesion. It interacts with its ligand, CD58, facilitating immune responses and cell-to-cell communication. CD2 Protein is also a potential target for immunotherapy and may contribute to the development of novel treatments for immune-related disorders. CD2 Protein, Human (HEK293, Fc) is the recombinant human-derived CD2 protein, expressed by HEK293 , with C-hFc labeled tag.
Background
The CD2 protein plays a pivotal role in mediating adhesion between T-cells and other cell types by interacting with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1. Beyond its adhesive function, CD2 is implicated in triggering T-cells, with its cytoplasmic domain serving a crucial role in signaling. CD2 also interacts with CD48 and CD58 (LFA-3), underscoring its involvement in cellular interactions. Additionally, CD2 engages with CD2AP and PSTPIP1, suggesting its versatility in cellular signaling pathways. Notably, the interaction between CD2 and FCGR3A modulates NK cell activation and cytotoxicity, highlighting the diverse roles of CD2 in immune cell functions.
Verified Bioactivity
Immobilized human CD58-His at 2 μg/mL (100 μL/well) can bind human CD2-Fc, the EC50 of human CD2-Fc is 14.1ng/mL.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-hFc
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Accession
P06729 (K25-D209)
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Molecular Construction
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N-term
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CD2 (K25-D209)
Accession # P06729 -
hFc
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C-term
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Protein Length
Extracellular Domain
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Synonyms
CD2; Rosette Receptor; Prev. SRBC; LFA-2; T-Cell Surface Antigen CD2; Lymphocyte-Function Antigen-2; CD2 Antigen (P50), Sheep Red Blood Cell Receptor; CD2 Antigen; T-Cell Surface Antigen T11/Leu-5; T11; Erythrocyte Receptor; CD2 Molecule; LFA-3 Receptor
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AA Sequence
KEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLD
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Predicted Molecular Mass
48 kDa
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (235 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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