country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-130588

Copy Link Print Information

Glutathione arsenoxide

(Synonyms: GSAO)

Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase.

For research use only. We do not sell to patients.

CAS No.: 1271726-51-2
Formula: C₁₈H₂₅AsN₄O₉S
Molecular Weight:548.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Glutathione arsenoxide Chemical Structure

CAS No.: 1271726-51-2

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Mitochondrial endomycin nucleotide transferase (ANT), Protein disulphide isomerase (PDI)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	270 μM Compound: GSAO	Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay	[PMID: 19788237]
HCT-116	IC₅₀	43 μM Compound: GSAO	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 19788237]
HMEC-1	IC₅₀	23 μM Compound: GSAO	Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay	[PMID: 19788237]
HT-1080	IC₅₀	25 μM Compound: GSAO	Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 19788237]
K562	IC₅₀	14 μM Compound: GSAO	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 19788237]
Lewis lung carcinoma cell line	IC₅₀	41 μM Compound: GSAO	Antiproliferative activity against mouse LLC cells after 72 hrs by MTT assay Antiproliferative activity against mouse LLC cells after 72 hrs by MTT assay	[PMID: 19788237]
MCF7	IC₅₀	51 μM Compound: GSAO	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 19788237]
MDCK-II	IC₅₀	13 μM Compound: GSAO	Antiproliferative activity against MDCK2 cells after 72 hrs by MTT assay Antiproliferative activity against MDCK2 cells after 72 hrs by MTT assay	[PMID: 19788237]
PANC-1	IC₅₀	43 μM Compound: GSAO	Antiproliferative activity against human PANC1 cells after 72 hrs by MTT assay Antiproliferative activity against human PANC1 cells after 72 hrs by MTT assay	[PMID: 19788237]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1271726-51-2
Molecular Weight 548.40
Formula C₁₈H₂₅AsN₄O₉S
SMILES

O=C(O)CNC([C@H](CSCC(NC1=CC=C([As](O)O)C=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)=O
Synonyms

GSAO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Park D, et al. The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell Int. 2012 Mar 26;12(1):11. [Content Brief]

[2]. Habeck M. Australian scientists design novel antiangiogenic weapon[J]. The Lancet Oncology, 2000, 1(4): 199.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote