1271726-51-2
Chemical Structure
Glutathione arsenoxide
Synonym(s): GSAO
- CAS No.: 1271726-51-2
- Formula:C18H25AsN4O9S
- Molecular Weight:548.40
IUPAC Name: N5-((R)-1-((carboxymethyl)amino)-3-((2-((4-(dihydroxyarsanyl)phenyl)amino)-2-oxoethyl)thio)-1-oxopropan-2-yl)-L-glutamine
InChIKey: ADJQAKCDADMLPP-STQMWFEESA-N
SMILES: O=C(O)CNC([C@H](CSCC(NC1=CC=C([As](O)O)C=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)=O
Biological Activity: Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase[1][2].
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Glutathione arsenoxide | Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase. | |||||||||||||||||||||
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- [1]. Park D, et al. The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell Int. 2012 Mar 26;12(1):11. [Content Brief]
- [2]. Habeck M. Australian scientists design novel antiangiogenic weapon[J]. The Lancet Oncology, 2000, 1(4): 199.
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