ICAM1/CD54 Antibody (YA6400)

Cat. No.: HY-P86708: Data Sheet User Guide for Antibodies
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ICAM1/CD54 Antibody (YA6400) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ICAM1/CD54 Antibody (YA6400) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 56 kDa

Species Reactivity

Human

SwissProt ID

P05362

Gene ID

3383 [NCBI]

Immunogen

Recombinant human ICAM1/CD54 aa 321-420/532

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1000
IHC-F IHC-F: Immunohistochemistry-Frozen	1:200-1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation|(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins|(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins|(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell

Subcellular Localization：Membrane

Expression：Induction: Up-regulated by coagulation factor Xa (F10) in atrial tissues (PubMed:24041930). Up-regulated in atrial tissues by rapid pacing resembling atrial fibrillation (PubMed:24041930)

Subunit：Homodimer (Probable)

Synonyms

BB2; CD54 antigen; CD54; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1(CD54), human rhinovirus receptor; major group rhinovirus receptor.

Documentation

User Guide for Antibodies (1077 KB)