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Etentamig

(Synonyms: ABBV-383; TNB 383B)
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Etentamig (ABBV-383; TNB 383B) is a T cell engager targeting BCMA and CD3. Etentamig redirects T cell-mediated cytotoxicity by binding BCMA (Kd ≈ 0.7 nM) and activating the T cell co-receptor CD3 (Kd = 1.3 μM), mediates BCMA-specific plasma cell killing and target cell lysis, and has low-activation properties that decouple T cell activation from cytokine release. Etentamig exhibits anti-myeloma efficacy and can be used for research on relapsed/refractory multiple myeloma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit : 99%
  • CAS. Nr.: 2490552-52-6
  • Molecular Weight:123.8 kDa
  • Speicherung:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Etentamig
  • Experimental Validation Results for Etentamig
  • Experimental Validation Results for Etentamig
  • Experimental Validation Results for Etentamig
  • Etentamig Chemical Structure
    Etentamig Chemical Structure
CAS. Nr.: 2490552-52-6
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Etentamig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    G4_L-kappa_VH-VH-h-CH2-CH3

  • 1/16

    Loaded ABBV-383 on AHC2 biosensor, can bind BCMA/TNFRSF17 Protein, Human (HEK293, His, HY-P72847) with an affinity constant of 1.731E-11 M as determined in BLI assay.

  • 1/16

    Loaded ABBV-383 on AHC2 biosensor, can bind CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His, HY-P70434) with an affinity constant of 3.674E-07 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1X106 Juakat cells with Etentamig (HY-P990785, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Etentamig Chemical Structure
    1/16
  • Etentamig
  • Loaded ABBV-383 on AHC2 biosensor, can bind BCMA/TNFRSF17 Protein, Human (HEK293, His, HY-P72847) with an affinity constant of 1.731E-11 M as determined in BLI assay.
  • Loaded ABBV-383 on AHC2 biosensor, can bind CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His, HY-P70434) with an affinity constant of 3.674E-07 M as determined in BLI assay.
  • Flow cytometric analysis of 1X106 Juakat cells with Etentamig (HY-P990785, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • G4_L-kappa_VH-VH-h-CH2-CH3