2. Inhibitory Antibodies
  3. Lorukafusp alfa

Lorukafusp alfa  (Synonyms: 14.18 mAb; hu14.18-IL2; EMD 273063)

Cat. No.: HY-P990076

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Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity.

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Lorukafusp alfa Chemical Structure

Lorukafusp alfa Chemical Structure

CAS No. : 2131168-99-3

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Lorukafusp alfa Related Antibodies

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Description

Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity[1].

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[Lorukafusp alfa]
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Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lorukafusp alfa2131168-99-314.18 mAb hu14.18-IL2 EMD 273063EMD273063EMD 273063EMD-273063Others14.18GD2IL210ADCCcomplement-dependent cytotoxicityhu14.18-IL2FcNKT cellsIL2 anti-tumorInhibitorinhibitorinhibit

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