CD146 Antibody (YA5482)
(Synonyms: Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD antigen CD146; )CD146 Antibody (YA5482) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD146.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
CD146 Antibody (YA5482) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD146.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 110 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 72 kDa
Synthesized peptide derived from human CD146 AA range: 500-600
Protein G
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:This gene can be detected in endothelial cells of vascular tissues throughout the body. During embryonic development, it may appear on the surface of neural crest cells as they migrate. In normal adult tissues, this gene appears to be limited to vascular smooth muscle. This gene is associated with tumor progression and metastasis in human malignant melanoma. It is most strongly expressed in metastatic lesions and advanced primary tumors, while it is rarely detected in benign melanocytic nevi and thin-layered primary melanomas with a low probability of metastasis. -
Isoforms & Post-Translational Modification
P43121 has 2 isomers: P43121-1: 71607 Da (predicted); P43121-2: 57605 Da (predicted).
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SwissProt ID
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Synonyms
Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD antigen CD146;
Documentation
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