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Cat. No.: HY-P85515

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Fas(C-term) Antibody (YA5207)

Name: Fas(C-term) Antibody (YA5207)
Brand: MedChemExpress
SKU: HY-P85515
Availability: PreOrder

(Synonyms: ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; Fas; TNF receptor superfamily, member 6; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; Fas cell surface death receptor; FAS1; FASLG receptor; FASTM; sFAS; Surface antigen APO1; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.)

Fas(C-term) Antibody (YA5207) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fas(C-term).

For research use only. We do not sell to patients.

Host:
Mouse
Application:
WB
Reactivity :
Human

Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot
Dilution Ratio	1:1000

Product Details

Description

Fas(C-term) Antibody (YA5207) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fas(C-term).

Host Mouse
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 45 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Immunogen

Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli.

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Product Properties

Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

Fas receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)
Subcellular Localization

Cell membrane; Single-pass type I membrane protein; Membrane raft; Secreted; Secreted; Secreted; Secreted; Secreted
Expression

Tissue_specificity:Subtype 1 and subtype 6 were expressed at equal levels in resting peripheral blood mononuclear cells. Upon activation, subtype 1 levels increased, while subtype 6 levels decreased.
Isoforms & Post-Translational Modification

P25445 has 7 isomers: P25445-1: 37732 Da (predicted); P25445-2: 11435 Da (predicted); P25445-3: 9390 Da (predicted); P25445-4: 16648 Da (predicted); P25445-5: 14602 Da (predicted); P25445-6: 35386 Da (predicted); P25445-7: 24781 Da (predicted).
(Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions;Palmitoylated (PubMed:25301068). Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane (PubMed:25301068);N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans
Subunit

Component of the death-induced signaling complex (DISC) composed of cell surface receptor FAS/CD95, adapter protein FADD and the CASP8 protease; recruitment of CASP8 to the complex is required for processing of CASP8 into the p18 and p10 subunits (PubMed:21109225, PubMed:9184224, PubMed:9322534).
SwissProt ID

P25445
Gene ID

355 [NCBI]
Synonyms

ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; Fas; TNF receptor superfamily, member 6; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; Fas cell surface death receptor; FAS1; FASLG receptor; FASTM; sFAS; Surface antigen APO1; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.