CD2 Antibody (YA5540)
(Synonyms: CD 2; CD2; CD2 antigen; p50; , sheep red blood cell receptor; CD2 antigen; CD2 molecule; CD2_HUMAN; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; LFA2; LFA3 receptor; Ly-37; Lymphocyte function antigen 2; lymphocyte-function antigen-2; OTTHUMP00000024366; Rosette receptor; Sheep erythrocyte receptor; SRBC; T cell surface antigen CD2; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T-lymphocyte surface CD2 antigen; T11)CD2 Antibody (YA5540) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD2.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
CD2 Antibody (YA5540) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 39 kDa
Synthesized peptide derived from human CD2 AA range: 1-100
Protein G
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD2 is a transmembrane glycoprotein primarily expressed on the surface of T cells, natural killer (NK) cells, and thymocytes, belonging to the immunoglobulin superfamily. It binds to LFA-3 on the cell surface and plays an important role in immune responses, especially in the formation and organization of the immunological synapse. CD2 enhances T cell activation by binding to LFA-3, thereby boosting immune responses. The expression of CD2 is upregulated on memory T cells and activated T cells, playing a crucial role in the activation of memory T cells. CD2 also plays a significant role in regulating immune cell functions, particularly in organ transplantation and certain autoimmune diseases. By inhibiting the CD2/LFA-3 co-stimulatory pathway, CD2 can reduce the excessive activation of T cells and NK cells, thereby lowering the risk of graft rejection and prolonging graft survival. Additionally, research indicates that CD2 plays a critical role in NK cell spontaneous cytotoxicity and certain cancer immune responses. Therefore, CD2 presents a broad application potential as an immune-regulatory target, especially in the study of autoimmune diseases and promoting immune tolerance in organ transplantation.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Expression (protein level) in natural killer cells -
Subunit
Interacts with CD58 (LFA-3) (PubMed:10380930). Interacts with PSTPIP1 (PubMed:9857189).
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SwissProt ID
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Synonyms
CD 2; CD2; CD2 antigen; p50; , sheep red blood cell receptor; CD2 antigen; CD2 molecule; CD2_HUMAN; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; LFA2; LFA3 receptor; Ly-37; Lymphocyte function antigen 2; lymphocyte-function antigen-2; OTTHUMP00000024366; Rosette receptor; Sheep erythrocyte receptor; SRBC; T cell surface antigen CD2; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T-lymphocyte surface CD2 antigen; T11
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