CD161 Antibody (YA4661)

Art. -Nr.: HY-P84969: Data Sheet User Guide for Antibodies
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CD161 Antibody (YA4661) is a non-conjugated antibody, targeting to CD161.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Größe		Verfügbarkeit
50 μL		Angebot einholen
100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

CD161 Antibody (YA4661) is a non-conjugated antibody, targeting to CD161.

SwissProt ID

Q12918

Gene ID

3820 [NCBI]

Reinheit	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in Phosphate-buffered solution.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells

Subcellular Localization：Membrane; Single-pass type II membrane protein

Expression：
Tissue_specificity:It is primarily expressed in NK cell subsets in the intestinal epithelium and liver. It can be detected in peripheral blood T cells, especially in adult T cells with a memory antigen phenotype.

Induction:By IL12/interleukin-12 in NK cells

Subunit：Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1

Synonyms

KLRB1; CLEC5B; NKRP1A; Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD161

Dokumentation

User Guide for Antibodies (1077 KB)