2. Gene
  3. KLRB1 - killer cell lectin like receptor B1 Gene

KLRB1 - killer cell lectin like receptor B1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A

Gene ID: 3820 | Gene type: protein coding

About KLRB1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,594,551-9,607,916 (from NCBI)

This gene has 1 transcript (splice variant), 326 orthologues and 23 paralogues. Broad expression in bone marrow (RPKM 31.5), spleen (RPKM 28.1) and 14 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]

KLRB1 Products(1)

mRNA Protein Name
NM_002258.3 NP_002249.1 killer cell lectin-like receptor subfamily B member 1

KLRB1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (114 - 212)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

killer cell lectin-like receptor subfamily B member 1

C-type lectin domain family 5 member B

Recombinant KLRB1 Proteins

Cat. No. Product Name Accession Purity
HY-P72750 CD161 Protein, Human (HEK293, Fc) Q12918 (Q67-S225) ≥95%
HY-P78085 CD161 Protein, Human (Biotinylated, HEK293, His-Avi) Q12918 (Q67-S225) ≥95%

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 18

IBD18
Dermatitis, Atopic, 5

ATOD5

Atopic Dermatitis 5

Dermatitis, Atopic, Susceptibility To, 5

Dermatitis, Atopic 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07390 KLRB1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KLRB1 RGD RGD:1586149
Macaca mulatta KLRB1 VGNC VGNC:99948
Canis familiaris KLRB1 VGNC VGNC:42485
Bos taurus KLRB1 VGNC VGNC:30684
Macaca fascicularis KLRB1 NCBI
Mus musculus KLRB1 NCBI
Others KLRB1 NCBI