CD83 Antibody (YA2260)
(Synonyms: CD83; CD83 antigen; hCD83; B-cell activation protein; Cell surface protein HB15; CD antigen CD83)CD83 Antibody (YA2260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD83.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
CD83 Antibody (YA2260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD83.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 23 kDa
A synthesized peptide derived from human CD83 aa50-95/205.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD83 is a Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections[1].
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells
Induction:Strongly up-regulated together with costimulatory molecules such as CD80 and CD86 during dendritic cell maturation -
Subunit
Monomer. Homodimer (PubMed:28315353). Homotrimer (PubMed:28315353). Interacts with MARCHF1; this interaction antagonizes MARCHF1-mediated MHC II and CD86 down-regulation (PubMed:21220452)
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SwissProt ID
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Synonyms
CD83; CD83 antigen; hCD83; B-cell activation protein; Cell surface protein HB15; CD antigen CD83
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Research Field
Immunology
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