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  4. Monoclonal Antibodies Recombinant Antibodies
  5. CD83 Antibody (YA2260)

CD83 Antibody (YA2260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD83.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
50 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
100 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

CD83 Antibody (YA2260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD83.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 23 kDa;
Observed band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human CD83 aa50-95/205.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed:21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity)
Subcellular Localization：Membrane; Single-pass type I membrane protein
Expression：
Tissue_specificity:Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells

Induction:Strongly up-regulated together with costimulatory molecules such as CD80 and CD86 during dendritic cell maturation
Subunit：Monomer. Homodimer (PubMed:28315353). Homotrimer (PubMed:28315353). Interacts with MARCHF1; this interaction antagonizes MARCHF1-mediated MHC II and CD86 down-regulation (PubMed:21220452)
Database

Entrez Gene: 9308 Human ;

SwissProt: Q01151 Human ;

OMIM: 604534 Human

Research Field

Immunology
Synonyms
CD83; CD83 antigen; hCD83; B-cell activation protein; Cell surface protein HB15; CD antigen CD83
Documentation
User Guide for Antibodies (1077 KB)

CD83 Antibody (YA2260) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CD83 Antibody (YA2260)
Cat. No.:
HY-P82515
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