CD83 - CD83 molecule Gene

Also Known as BL11; HB15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9308

About CD83

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:14,117,256-14,136,918 (from NCBI)

This gene has 2 transcripts (splice variants) and 120 orthologues. Broad expression in bone marrow (RPKM 72.2), lymph node (RPKM 25.8) and 14 other tissues.

Summary

The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

CD83 Products (3)

mRNA	Protein	Name
NM_001040280.3	NP_001035370.1	CD83 antigen isoform b precursor
NM_001251901.1	NP_001238830.1	CD83 antigen isoform c
NM_004233.4	NP_004224.1	CD83 antigen isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20374249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD83 Protein Structure

V-set

0
100
205 a.a.

Protein Preferred Names	Protein Names
CD83 antigen	B-cell activation protein

CD83 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD83	Q01151	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	CD83	Q01151	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	CD83	Q01151	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD83 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72703	CD83 Protein, Human (HEK293, Fc)	Q01151 (T20-A143)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75377	CD83 Protein, Human (HEK293, His)	Q01151 (T20-A143)	≥ 90%, as determined by reducing SDS-PAGE.

CD83 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82515	CD83 Antibody (YA2260)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection
Sulfamethoxazole Allergy	Smx Allergy Smz Allergy Sulphamethoxazole Allergy
Herpes Zoster	Shingles Zoster Herpes Zona Herpes Zoster Disease Zona Zoster Herpes Zoster Of Skin And Mucous Membranes Zoster Nos Zoster With Nervous System Involvement
Rift Valley Fever	Rfv - [Rift Valley Fever]
Anal Gland Neoplasm	Anal Gland Neoplasms
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction	Left Ventricular Noncompaction 3 Dilated Cardiomyopathy 1c CMD1C Cardiomyopathy, Hypertrophic, 24 Dilated Cardiomyopathy With Left Ventricular Noncompaction Cardiomyopathy, Dilated, 1c, With Or Without Lvnc Cmdc1 Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction Cardiomyopathy Dilated With Left Ventricular Noncompaction Cardiomyopathy, Familial Hypertrophic 24 CMH24 Left Ventricular Non-Compaction 3 LVNC3 Cardiomyopathy, Dilated 1c Familial Hypertrophic Cardiomyopathy 24 Cardiomyopathy, Dilated, 1c
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991424	GSK2618960	Inhibitor	95.66%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N10116A	Calamenene		/	Unkown
HY-176755	CCL-34	Activator	/	Unkown
HY-RS02272	CD83 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17582	Cd83 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24042	Cd83 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990360	Anti-CD9 Antibody		99.52%	Unkown
HY-P990261	Anti-Mouse CD83 Antibody (Michel-17)	Inhibitor	98.722%	Unkown
HY-P992330	CBT004	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD83	VGNC	VGNC:38977
Mus musculus	CD83	MGD	MGI:1328316
Felis catus	CD83	VGNC	VGNC:60641
Rattus norvegicus	CD83	RGD	RGD:1309677
Bos taurus	CD83	VGNC	VGNC:27050
Macaca mulatta	CD83	VGNC	VGNC:70783
Others	CD83	NCBI