1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. Geldanamycin-FITC

Geldanamycin-FITC 

Cat. No.: HY-133705
Handling Instructions

Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90.

For research use only. We do not sell to patients.

Geldanamycin-FITC Chemical Structure

Geldanamycin-FITC Chemical Structure

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Description

Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90[1][2][3].

IC50 & Target[1]

HSP90

 

In Vitro

The HSP90 inhibitor Geldanamycin, when conjugated with FITC (GA–FITC) is cell-membrane impermeable, binding only cell surface HSP90 and inhibiting its functions but having no effect on cytosolic HSP90[3].

Molecular Weight

1034.18

Formula

C₅₅H₆₃N₅O₁₃S

SMILES

O=C(C(NCCCCCCNC(NC1=CC=C(C(C(C=CC(O)=C2)=C2O3)=C4C3=CC(C=C4)=O)C(C(O)=O)=C1)=S)=C5C[[email protected]@H](C)C[[email protected]](OC)[[email protected]](O)[[email protected]@H](C)/C=C6C)C=C(NC(/C(C)=C/C=C\[[email protected]](OC)[[email protected]]\6OC(N)=O)=O)C5=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Geldanamycin-FITCHSPHeat shock proteinsfluorescencepolarizationassaycell-membranecytosolicInhibitorinhibitorinhibit

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Geldanamycin-FITC
Cat. No.:
HY-133705
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