2969156-01-0
Chemical Structure
Geldanamycin-FITC
- CAS No.: 2969156-01-0
- Formula:C55H63N5O13S
- Molecular Weight:1034.18
IUPAC Name: 5-(3-(6-(((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-(carbamoyloxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-19-yl)amino)hexyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
InChIKey: NLCWMGUTUFWVHY-CPMGOHQRSA-N
SMILES: O=C(C(NCCCCCCNC(NC1=CC=C(C(C(C=CC(O)=C2)=C2O3)=C4C3=CC(C=C4)=O)C(C(O)=O)=C1)=S)=C5C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C6C)C=C(NC(/C(C)=C/C=C\[C@H](OC)[C@H]\6OC(N)=O)=O)C5=O
Biological Activity: Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90 (Ex/Em = 488/515 nm)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Geldanamycin-FITC | 92.56% | Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90 (Ex/Em = 488/515 nm). | ||||||||||||||||||||
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- [1]. Kim J, et al. Development of a fluorescence polarization assay for the molecular chaperone Hsp90. J Biomol Screen. 2004;9(5):375‐381. [Content Brief]
- [2]. Posfai D, et al. Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. Antimicrob Agents Chemother. 2018;62(4):e01799-17. Published 2018 Mar 27. [Content Brief]
- [3]. Imai T, et al. Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A. 2011;108(39):16363‐16368. [Content Brief]
Keywords
