CD8 beta Antibody (YA6503)

CD8 beta Antibody (YA6503) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD8 beta.

Predicted band size: 24 kDa;

P10966

926 [NCBI]

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Function：Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells

Subcellular Localization：Cell membrane,Cell membrane,Secreted,Cell membrane,Cell membrane,Secreted,Secreted,Secreted

Expression：
Tissue_Specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells

Isoforms & Post-Translational Modification：P10966 has 8 isomers: P10966-1: 23722 Da (predicted); P10966-2: 25027 Da (predicted); P10966-3: 24276 Da (predicted); P10966-4: 27681 Da (predicted); P10966-6: 27246 Da (predicted); P10966-7: 20752 Da (predicted); P10966-8: 23633 Da (predicted); P10966-9: 22237 Da (predicted).
Phosphorylated as a consequence of T-cell activation丨Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers

Subunit：Forms disulfide-linked heterodimers with CD8A at the cell surface

CD8b antigen antibody; CD_antigen=CD8b antibody; CD8 antigen 37 kDa chain antibody; CD8 antigen beta polypeptide 1 (p37) antibody; CD8 antigen beta polypeptide 1 antibody; CD8 antigen, beta chain antibody; CD8 antigen, beta polypeptide 1 (p37) antibody; CD8 antigen, beta polypeptide 1 antibody; CD8 beta antibody; CD8b antibody; CD8b antigen antibody; CD_antigen=CD8b antibody; CD8 antigen 37 kDa chain antibody; CD8 antigen beta polypeptide 1 (p37) antibody; CD8 antigen beta polypeptide 1 antibody; CD8 antigen, beta chain antibody; CD8 antigen, beta polypeptide 1 (p37) antibody; CD8 antigen, beta polypeptide 1 antibody; CD8 beta antibody; CD8b antibody; CD8b molecule antibody; CD8B_HUMAN antibody; CD8B1 antibody; Flags: Precursor antibody; Leu2 antibody; Ly3 antibody; LYT3 antibody; MGC119115 antibody; OTTHUMP00000160762 antibody; OTTHUMP00000160763 antibody; OX 8 membrane antigen antibody; P37 antibody; T cell surface glycoprotein CD8 antibody; T cell surface glycoprotein CD8 beta chain antibody; T lymphocyte surface glycoprotein beta chain antibody; T-cell surface glycoprotein CD8 beta chain antibody;