CD8B - CD8b molecule Gene

Also Known as LY3; P37; LEU2; LYT3; Ly-3; CD8B1; CD8beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 926

About CD8B

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:86,815,369-86,861,886 (from NCBI)

This gene has 6 transcripts (splice variants), 171 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 4.6), small intestine (RPKM 2.3) and 14 other tissues.

Summary

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

CD8B Products (5)

mRNA Protein Name
NM_001178100.2 NP_001171571.1 T-cell surface glycoprotein CD8 beta chain isoform 6 precursor
NM_004931.5 NP_004922.1 T-cell surface glycoprotein CD8 beta chain isoform 5 precursor
NM_172101.5 NP_742099.1 T-cell surface glycoprotein CD8 beta chain isoform 3 precursor
NM_172102.5 NP_742100.1 T-cell surface glycoprotein CD8 beta chain isoform 4 precursor
NM_172213.5 NP_757362.1 T-cell surface glycoprotein CD8 beta chain isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2493728 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell activation IDA
IDA: Inferred from direct assay
17145893 GOA
involved in T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
17145893 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD8B Protein Structure

V-set

V-set: Immunoglobulin V-set domain (20 - 134)

  • 0
  • 100
  • 200
  • 210 a.a.
Protein Preferred Names Protein Names

T-cell surface glycoprotein CD8 beta chain

  • CD8 antigen, beta polypeptide 1 (p37)

Recombinant CD8B Proteins

Cat. No. Product Name Accession Purity
HY-P72702 CD8 beta Protein, Human (HEK293, His) P10966-1 (L22-P170) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74265 CD8 beta Protein, Human (HEK293, Fc) P10966-1 (L22-P170) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74266 CD8 beta Protein, Human (HEK293) P10966-1 (L22-P170) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P77519 CD8 beta Protein, Human (Biotinylated, HEK293) P10966-1 (L22-P170) ≥ 90%, as determined by reducing SDS-PAGE.

CD8B Antibodies

Cat. No. Product Name Application Reactivity
HY-P86810 CD8 beta Antibody (YA6503) WB, ICC/IF, IHC-P, FC Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02276 CD8B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25091 Cd8b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CD8B MGD MGI:88347
Rattus norvegicus CD8B RGD RGD:2317
Others CD8B NCBI