CD8B - CD8b molecule Gene

Homo sapiens

Also known as LY3; P37; LEU2; LYT3; Ly-3; CD8B1; CD8beta

Gene ID: 926 | Gene type: protein coding

About CD8B

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:86,815,369-86,861,886 (from NCBI)

This gene has 6 transcripts (splice variants), 171 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 4.6), small intestine (RPKM 2.3) and 14 other tissues.

Summary

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable LIGHT chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

CD8B Products(5)

mRNA	Protein	Name
NM_001178100.2	NP_001171571.1	T-cell surface glycoprotein CD8 beta chain isoform 6 precursor
NM_004931.5	NP_004922.1	T-cell surface glycoprotein CD8 beta chain isoform 5 precursor
NM_172101.5	NP_742099.1	T-cell surface glycoprotein CD8 beta chain isoform 3 precursor
NM_172102.5	NP_742100.1	T-cell surface glycoprotein CD8 beta chain isoform 4 precursor
NM_172213.5	NP_757362.1	T-cell surface glycoprotein CD8 beta chain isoform 2 precursor

CD8B Protein Structure

V-set

0
100
210 a.a.

Protein Preferred Names

Protein Names

T-cell surface glycoprotein CD8 beta chain

CD8 antigen, beta polypeptide 1 (p37)

Recombinant CD8B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72702	CD8 beta Protein, Human (HEK293, His)	P10966 (L22-P170)	≥95%
HY-P74265	CD8 beta Protein, Human (HEK293, Fc)	P10966 (M1-P170)	≥95%
HY-P74266	CD8 beta Protein, Human (HEK293)	P10966 (M1-P170)	≥95%
HY-P77519	CD8 beta Protein, Human (Biotinylated, HEK293)	P10966 (M1-P170)	≥95%

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02276	CD8B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD8B	MGD	MGI:88347
Rattus norvegicus	CD8B	RGD	RGD:2317
Others	CD8B	NCBI