Solimastat  (Synonyms: BB-3644)

Solimastat (BB-3644) is a potent metalloproteinase (MMP) inhibitor that blocks constitutive and antibody-stimulated CD30 shedding from cell surfaces with an IC₅₀ of 180 nM. Solimastat enhances persistence of anti-CD30 antibody Ki-3 on cells and favors its internalization. Solimastat enhances cytotoxic activity of Ki-3.dgA towards CD30⁺ L540 cells. Solimastat can be used for the research of CD30⁺ malignancies^[1].

Solimastat (0-10⁵ nM, 10 min) potently inhibits PMA (HY-18739)-induced CD30 shedding from Karpas 299 cells in a dose-dependent manner^[1].
Solimastat (5 μM; 12 h) significantly increases internalization and surface persistence of Ki-3 MAb in Karpas 299 cells, while showing no effect on the process of antibody endocytosis itself^[1].
Solimastat (5 μM; 48 h) increases the cytotoxic activity of Ki-3.dgA immunotoxin against L540 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

408.50

C₂₀H₃₂N₄O₅

226072-63-5

[C@@H]([C@@H](C(NO)=O)OC)(C(N[C@H](C(NC1=CC=CC=N1)=O)[C@@](C)(C)C)=O)CC(C)C

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• [1]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002;98(2):210-215.  [Content Brief]