226072-63-5
Chemical Structure
Solimastat
Synonym(s): BB-3644
- CAS No.: 226072-63-5
- Formula:C20H32N4O5
- Molecular Weight:408.50
IUPAC Name: (2R,3S)-N1-((S)-3,3-dimethyl-1-oxo-1-(pyridin-2-ylamino)butan-2-yl)-N4-hydroxy-2-isobutyl-3-methoxysuccinamide
InChIKey: WORSVFBVUCBRIP-VNQPRFMTSA-N
SMILES: [C@@H]([C@@H](C(NO)=O)OC)(C(N[C@H](C(NC1=CC=CC=N1)=O)[C@@](C)(C)C)=O)CC(C)C
Biological Activity: Solimastat (BB-3644) is a potent metalloproteinase (MMP) inhibitor that blocks constitutive and antibody-stimulated CD30 shedding from cell surfaces with an IC50 of 180 nM. Solimastat enhances persistence of anti-CD30 antibody Ki-3 on cells and favors its internalization. Solimastat enhances cytotoxic activity of Ki-3.dgA towards CD30+ L540 cells. Solimastat can be used for the research of CD30+ malignancies[1].
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Solimastat | Solimastat (BB-3644) is a potent metalloproteinase (MMP) inhibitor that blocks constitutive and antibody-stimulated CD30 shedding from cell surfaces with an IC50 of 180 nM. Solimastat enhances persistence of anti-CD30 antibody Ki-3 on cells and favors its internalization. Solimastat enhances cytotoxic activity of Ki-3.dgA towards CD30+ L540 cells. Solimastat can be used for the research of CD30+ malignancies. | |||||||||||||||||||||
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Keywords
