2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. CD11b Antibody (YA546)(PBS only)

CD11b Antibody (YA546)(PBS only)

製品番号: HY-P80592A
User Guide for Antibodies Technical Support

CD11b Antibody (YA546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

CD11b Antibody (YA546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.
Host

Rabbit
分子量
Predicted band size: 127 kDa;
Observed band size: 170 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Mouse
SwissProt ID
Gene ID
Immunogen

Synthetic peptide corresponding to Mouse CD11b.The exact sequence is proprietary to MCE.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:20
純度 affinity purified Conjugation Non-conjugated
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038)
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Membrane raft; Single-pass type I membrane protein
Expression：
Tissue_specificity:Predominantly expressed in monocytes and granulocytes (PubMed:3887182, PubMed:8986723) . Expressed in a subset of peritoneal mast cells (PubMed:9862668) . Expressed in microglia (at protein level) (PubMed:18685038)

Induction:Induced by lipopolysaccharide (LPS) in mast cells
Isoforms & Post-Translational Modification：P05555 has 2 isomers: P05555-1: 127481 Da (predicted); P05555-2: 115196 Da (predicted).
Subunit：Heterodimer of an alpha and a beta subunit. ITGAM associates with ITGB2. Found in a complex with CD177 and ITGB2/CD18. Interacts with JAM3. Interacts with THBD. Interacts with complement factor H/CFH; this interaction mediates adhesion of neutrophils to pathogens leading to pathogen clearance (By similarity). Interacts with TMEM268; this interaction inhibits ITGAM degradation via the endosome-lysosome pathway (By similarity)
Research Field

Neuroscience
Synonyms
CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; CD11b; Leukocyte adhesion receptor MO1
ドキュメンテーション
User Guide for Antibodies (1077 KB)

CD11b Antibody (YA546)(PBS only) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
CD11b Antibody (YA546)(PBS only)
製品番号:
HY-P80592A
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