Itgam - integrin alpha M Gene

Also Known as CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16409

Summary

Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of Integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (Integrin subunit alpha M). [provided by Alliance of Genome Resources, Apr 2022]

Itgam Products (3)

mRNA Protein Name
NM_001082960.1 NP_001076429.1 integrin alpha-M isoform 1 precursor
NM_008401.2 NP_032427.2 integrin alpha-M isoform 2 precursor
NM_008401.2 NP_032427.2 integrin alpha-M isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cargo receptor activity IGI
IGI: Inferred from genetic interaction
22438044 MGI
contributes to cargo receptor activity IMP
IMP: Inferred from mutant phenotype
20199584 MGI
enables complement component C3b binding IGI
IGI: Inferred from genetic interaction
20199584 MGI
enables heparan sulfate proteoglycan binding IDA
IDA: Inferred from direct assay
8043862 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
8043862 MGI
enables opsonin binding IDA
IDA: Inferred from direct assay
12163569 MGI
enables opsonin binding IMP
IMP: Inferred from mutant phenotype
12163569 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
28228282 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
15210787 MGI
involved in amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
20199584 MGI
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
22438044 MGI
acts upstream of or within cell adhesion IGI
IGI: Inferred from genetic interaction
19342649 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
10528208 MGI
acts upstream of or within cell-cell adhesion IGI
IGI: Inferred from genetic interaction
16093349 MGI
acts upstream of or within cellular extravasation IMP
IMP: Inferred from mutant phenotype
10528208 MGI
involved in complement receptor mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22632727 MGI
involved in complement-mediated synapse pruning IMP
IMP: Inferred from mutant phenotype
22632727 MGI
involved in forebrain development IDA
IDA: Inferred from direct assay
18685038 MGI
involved in leukocyte adhesion to vascular endothelial cell IMP
IMP: Inferred from mutant phenotype
8986723 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8562500 MGI
acts upstream of or within leukocyte migration involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
23550035 MGI
acts upstream of or within microglia development IDA
IDA: Inferred from direct assay
20578039 MGI
involved in microglial cell activation IMP
IMP: Inferred from mutant phenotype
18981141 MGI
involved in negative regulation of dopamine metabolic process IDA
IDA: Inferred from direct assay
18981141 MGI
involved in neutrophil apoptotic process IMP
IMP: Inferred from mutant phenotype
8986723 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
10528208 MGI
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
8986723 MGI
involved in phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
20199584 MGI
involved in positive regulation of mast cell differentiation IMP
IMP: Inferred from mutant phenotype
9862668 MGI
involved in positive regulation of microglial cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
18685038 MGI
involved in positive regulation of prostaglandin-E synthase activity IMP
IMP: Inferred from mutant phenotype
18981141 MGI
involved in positive regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
18981141 MGI
involved in positive regulation of superoxide anion generation IDA
IDA: Inferred from direct assay
18685038 MGI
involved in positive regulation of superoxide anion generation IMP
IMP: Inferred from mutant phenotype
18981141 MGI
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
20199584 MGI
involved in vertebrate eye-specific patterning IMP
IMP: Inferred from mutant phenotype
22632727 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
9324354 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8043862 MGI
part of integrin alphaM-beta2 complex IMP
IMP: Inferred from mutant phenotype
20199584 MGI
located in membrane IDA
IDA: Inferred from direct assay
12529407 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15138196 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8986723 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-M

  • CD11 antigen-like family member B

  • CD11B (p170)

  • CR-3 alpha chain

  • Mac-1 alpha

  • cell surface glycoprotein MAC-1 alpha subunit

  • cell surface glycoprotein MAC-1 subunit alpha

  • complement receptor type 3

  • leukocyte adhesion receptor MO1

  • macrophage antigen a

Itgam Antibodies

Cat. No. Product Name Application Reactivity
HY-P80592 CD11b Antibody (YA546) WB, IP Mouse
HY-P80592A CD11b Antibody (YA546)(PBS only) WB, IP Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156794 Enzomenib Inhibitor 99.88% Unkown
HY-RS20044 Itgam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156794A Enzomenib enantiomer Inhibitor 98.01% Unkown
HY-RS06960 ITGAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26547 Itgam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgam NCBI NCBI:3684