CD4 Antibody (YA4686)
(Synonyms: T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD antigen CD4; CD4 nanobody; )Based on 1 Customer Validation
CD4 Antibody (YA4686) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD4.
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Host:
Mouse
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Isotype:
IgG
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in 0.01M PBS (pH7.4).
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 1ug/Test |
Product Details
CD4 Antibody (YA4686) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
KLH conjugated synthetic peptide derived from human CD4
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M PBS (pH7.4).
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
The CD4 protein, an integral membrane glycoprotein, assumes a crucial role in immune responses, undertaking diverse functions against both external and internal challenges. In T-cells, its primary function is as a coreceptor for the MHC class II molecule:peptide complex, where class II peptides originate from extracellular proteins, while class I peptides are derived from cytosolic proteins. CD4 interacts concurrently with the T-cell receptor (TCR) and the MHC class II presented by antigen-presenting cells (APCs)， leading to the recruitment of the Src kinase LCK to the vicinity of the TCR-CD3 complex. Subsequently, LCK initiates various intracellular signaling pathways by phosphorylating diverse substrates, ultimately resulting in lymphokine production, enhanced motility, adhesion, and the activation of T-helper cells. In other cell types such as macrophages or NK cells, CD4 contributes to differentiation/activation, cytokine expression, and cell migration through a TCR/LCK-independent pathway. Additionally, it plays a pivotal role in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. Notably, CD4 acts as the primary receptor for human immunodeficiency virus-1 (HIV-1)， with its down-regulation facilitated by HIV-1 Vpu, and it also serves as a receptor for Human Herpes virus 7/HHV-7.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_Specificity: Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells -
Isoforms & Post-Translational Modification
CD4: 458 amino acids, molecular weight 51111 Da.
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Subunit
Forms disulfide-linked homodimers at the cell surface
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SwissProt ID
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Synonyms
T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD antigen CD4; CD4 nanobody;
Documentation
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Data Sheet (230 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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User Guide for Antibodies (1077 KB)
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