ICAM1/CD54 Antibody (YA6400)(PBS only)
(Synonyms: BB2; CD54 antigen; CD54; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1(CD54), human rhinovirus receptor; major group rhinovirus receptor.)ICAM1/CD54 Antibody (YA6400) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, IHC-F, IF-Tissue
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:200-1000 | 1:200-1000 |
Product Details
ICAM1/CD54 Antibody (YA6400) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 56 kDa
Recombinant human ICAM1/CD54 aa 321-420/532
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ICAM1/CD54 is an ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation|(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins|(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins|(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell
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Subcellular Localization
Membrane
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Expression
Induction: Up-regulated by coagulation factor Xa (F10) in atrial tissues (PubMed:24041930). Up-regulated in atrial tissues by rapid pacing resembling atrial fibrillation (PubMed:24041930)
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Isoforms & Post-Translational Modification
P05362: 532 amino acids, molecular weight 57825 Da.
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Subunit
Homodimer (Probable)
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SwissProt ID
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Synonyms
BB2; CD54 antigen; CD54; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1(CD54), human rhinovirus receptor; major group rhinovirus receptor.
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