Neuraminidase, arthrobacter ureafaciens 

Neuraminidase, arthrobacter ureafaciens is a neuraminidase derived from Arthrobacter ureafaciens. Neuraminidase, arthrobacter ureafaciens catalyzes the removal of sialic acid residues from cell surfaces and viral glycoconjugates. Neuraminidase, arthrobacter ureafaciens enhances HIV-1-mediated syncytium formation and promotes the viral binding and entry steps in the HIV-1 replication cycle^[1][2].

Neuraminidase from *Arthrobacter ureafaciens* (0.01 U/mL; 16 h) enhances HIV-1-mediated syncytium formation in 1G5/J1.1, Jurkat E6.1/J1.1, and PHA/IL-2-stimulated PBMC/J1.1 cell mixtures, and this effect is observed after 16 h of incubation^[1].
Neuraminidase from *Arthrobacter ureafaciens* (0.01 U/mL; 16 h) enhances HIV-1-induced syncytium formation in the 1G5/J1.1 cell mixture. This effect depends on the interaction between gp120 and CD4/chemokine co-receptors, and becomes observable after 16 h of incubation^[1].
Neuraminidase from *Arthrobacter ureafaciens* (0.1 U/mL; 120 min) enhances the adhesion and invasion of HIV-1 to Jurkat cells, increasing the level of viral internalization by 5-fold^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9001-67-6

Liquid

Colorless to light yellow

[Neuraminidase, arthrobacter ureafaciens]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sun J, et al. Neuraminidase from a bacterial source enhances both HIV-1-mediated syncytium formation and the virus binding/entry process. Virology. 2001;284(1):26-36.

  [2]. Maru I, et al. Synthesis of sialyllactose from N-acetylneuraminic acid and lactose by a neuraminidase from Arthrobacter ureafaciens[J]. Bioscience, biotechnology, and biochemistry, 1992, 56(10): 1557-1561.