CD105/Endoglin Protein, Mouse (HEK293, His, solution)

CD105/Endoglin, a vascular endothelium glycoprotein, plays a crucial role in angiogenesis regulation, contributing to the normal structure and integrity of adult vasculature. Essential for maintaining the structural integrity of the vasculature, CD105/Endoglin also influences the migration of vascular endothelial cells. Its significance extends to extraembryonic angiogenesis and embryonic heart development, underscoring its essential role in vascular development. CD105/Endoglin may modulate endothelial cell responses to blood flow, impacting vascular remodeling and the establishment of normal vascular morphology during angiogenesis. Functioning as a TGF-beta coreceptor, it is involved in the TGF-beta/BMP signaling cascade, leading to the activation of SMAD transcription factors. Furthermore, CD105/Endoglin interacts with various molecules, including TGFB1, GDF2, ACVRL1, BMP10, DYNLT4, and ARRB2, highlighting its multifaceted involvement in cellular processes. The protein forms homodimers through disulfide linkages and engages in heteromeric complexes with TGF-beta signaling receptors. Additionally, CD105/Endoglin binds TGFB1 and TGFB2 with high affinity, further emphasizing its intricate role in molecular interactions.