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Eng - endoglin Gene

Also Known as Endo; CD105; S-endoglin

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13805

Summary

Enables protein homodimerization activity and transforming growth factor beta binding activity. Involved in several processes, including circulatory system development; positive regulation of cell differentiation; and regulation of gene expression. Acts upstream of or within circulatory system development and positive regulation of angiogenesis. Located in endothelial microparticle. Is expressed in several structures, including brain; cardiovascular system; extraembryonic vascular system; and lung. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin). [provided by Alliance of Genome Resources, Apr 2022]

Eng Products (3)

mRNA	Protein	Name
NM_001146348.1	NP_001139820.1	endoglin isoform 3 precursor
NM_001146350.1	NP_001139822.1	endoglin isoform 2 precursor
NM_007932.2	NP_031958.2	endoglin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23868260	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8194490	MGI
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	8194490	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	10625534	MGI
involved in artery morphogenesis	IMP IMP: Inferred from mutant phenotype	10348742	MGI
involved in atrial cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	17628518	MGI
involved in atrioventricular canal morphogenesis	IMP IMP: Inferred from mutant phenotype	19703439	MGI
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	10348742	MGI
involved in cardiac atrium morphogenesis	IMP IMP: Inferred from mutant phenotype	19703439	MGI
NOT involved in cardiac jelly development	IMP IMP: Inferred from mutant phenotype	19703439	MGI
involved in cardiac ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	19703439	MGI
acts upstream of or within cell migration involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	19703439	MGI
involved in dorsal aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	12941632	MGI
involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	12941632	MGI
NOT involved in endocardial cushion to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	12941632	MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	19703439	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10562296	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	10348742	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	12941632	MGI
involved in outflow tract septum morphogenesis	IGI IGI: Inferred from genetic interaction	17628518	MGI
acts upstream of or within positive regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	23868260	MGI
involved in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	19703439	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19703439	MGI
involved in positive regulation of vascular associated smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	17628518	MGI
NOT involved in regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17628518	MGI
NOT involved in regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	17628518	MGI
NOT involved in regulation of cell proliferation involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17628518	MGI
involved in smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	10348742	MGI
NOT involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19703439	MGI
involved in vascular associated smooth muscle cell development	IMP IMP: Inferred from mutant phenotype	17628518	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	10562296	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	10348742	MGI
involved in venous blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	10348742	MGI
involved in ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	19703439	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endothelial microparticle	IDA IDA: Inferred from direct assay	20978343	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
endoglin	cell surface MJ7/18 antigen transmembrane glycoprotein

Recombinant Eng Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75446	CD105/Endoglin Protein, Mouse (HEK293, His, solution)	Q63961 (R28-G581)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-186189	OPA-S-S-alkyne		/	Unkown
HY-RS04374	ENG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W782599	Senkyunolide B	Inhibitor	/	Unkown
HY-RS17441	Eng Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23897	Eng Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eng	NCBI	NCBI:2022