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Results for "

Ligand-linker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (800) Target Protein Ligand-Linker Conjugates (76) 17β-HSD (1) ADC Linker (1) Akt (3) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (7) Apoptosis (153) ATM/ATR (1) AUTACs (1) Autophagy (141) AUTOTACs (1) Bcl-2 Family (2) BCL6 (1) Btk (4) c-Met/HGFR (4) c-Myc (3) Caspase (1) CCR (1) CDK (7) Checkpoint Kinase (Chk) (1) CRM1 (1) Cytochrome P450 (1) Deubiquitinase (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (2) EGFR (3) Enterovirus (1) Epigenetic Reader Domain (19) ERK (3) Estrogen Receptor/ERR (4) FAK (1) Fat Mass and Obesity-associated Protein (FTO) (1) FGFR (1) FKBP (5) FLT3 (4) Fluorescent Dye (1) Glutathione Peroxidase (1) HDAC (5) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (2) Histone Methyltransferase (5) HSP (2) HyT (1) IAP (3) IKZF Family (1) JAK (3) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (7) LYTACs (1) MAGL (1) MAP4K (2) METTL3 (1) Mitophagy (1) Mixed Lineage Kinase (1) Molecular Glues (1) NF-κB (2) Oxysterol-binding Protein-related Protein (ORP) (1) PARP (1) PD-1/PD-L1 (2) PI3K (1) PIKfyve (1) Pim (1) Pregnane X Receptor (PXR) (2) PROTAC-Linker Conjugates for PAC (2) PROTACs (62) Proteasome (1) Ras (6) Reference Standards (17) RET (2) RIBOTAC (1) RIP kinase (2) SGK (2) Src (1) STAT (4) SWI/SNF Complex (3) Wee1 (1) YAP (2) YTHDF (1)
By Research Areas:	Cancer (866) Infection (7) Inflammation/Immunology (18) Metabolic Disease (3) Neurological Disease (4)
Click Chemistry:	PROTAC Synthesis (6) Azide (33) Alkynes (12)
Oligonucleotides:	Pegylated Lipids (1)

964

Inhibitors & Agonists

Biochemical Assay Reagents

Click Chemistry

Oligonucleotides

Targets Recommended: Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-43869

*Vipivotide tetraxetan Ligand-Linker* Conjugate** PSMA-617 Ligand-linker Conjugate	ADC Linker	Cancer
Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is a complex composed of pharmacophore group Glutamate-urea-Lysine peptide coupling linker, which can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine selectively binds to prostate-specific membrane antigen (PSMA) .

HY-175360

*USP7 Ligand-Linker* Conjugates 1**	Target Protein Ligand-Linker Conjugates Deubiquitinase	Cancer
USP7 Ligand-Linker Conjugates 1 is an *Target Protein Ligand-Linker* Conjugate** that incorporates a ligand for USP7 (HY-175359) and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358) .

HY-175766

*CRBN Ligand-Linker* Conjugate 2**	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
CRBN Ligand-Linker Conjugate 2 is a synthesized E3 ligand-linker conjugate that can be used for synthesis of PROTACs, such as FIP22 (HY-175764). FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity .

HY-176918

*K-Ras ligand-Linker* Conjugate 8**	Target Protein Ligand-Linker Conjugates Ras	Cancer
K-Ras ligand-Linker Conjugate 8 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for KRAS (HY-162960) and a PROTAC linker, which recruits E3 ligases. K-Ras ligand-Linker Conjugate 8 can be used for synthesis of PROTAC KRAS(on) degrader ACBI-4 (HY-176792) .

HY-175551

*HPK1 ligand-Linker* Conjugate 1**	Target Protein Ligand-Linker Conjugates MAP4K	Cancer
HPK1 ligand-Linker Conjugate 1 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5 (HY-175547). PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity .

HY-175726

*BRAF ligand-Linker* Conjugate 1**	Target Protein Ligand-Linker Conjugates	Cancer
BRAF ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC CST905(HY-175435) .

HY-179244

*E3 Ligase Ligand-linker* Conjugate 215**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 215 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 215 can be used to synthesize STAT3 PROTAC Degrader S3D5 (HY-179243) .

HY-175374

*RIPK1 ligand-Linker* Conjugate-1**	Target Protein Ligand-Linker Conjugates RIP kinase	Cancer
RIPK1 ligand-Linker Conjugate-1 is a *Target Protein Ligand-Linker* Conjugate** that incorporates a ligand for RIPK1 (HY-175371) and a PROTAC linker (HY-175373), which recruits E3 ligases. RIPK1 ligand-Linker Conjugate-1 can be used for synthesis of PROTAC RIPK1 Degrader-1 (HY-175370) .

HY-176788

*EGFR Ligand-Linker* Conjugates 1**	Target Protein Ligand-Linker Conjugates EGFR	Cancer
EGFR Ligand-Linker Conjugates 1 is an *Target Protein Ligand-Linker* Conjugate** that incorporates a ligand for EGFR (HY-150905) and a PROTAC linker, which recruits E3 ligases. EGFR Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC EGFR degrader 3 (HY-144605) .

HY-178046

*OSBP ligand-Linker* Conjugate 1**	Oxysterol-binding Protein-related Protein (ORP) Target Protein Ligand-Linker Conjugates	Cancer
OSBP ligand-Linker Conjugate 1 is a *Target Protein Ligand-Linker* Conjugate** that incorporates a ligand for OSBP (HY-178035) and a PROTAC linker, which recruits E3 ligases. OSBP ligand-Linker Conjugate 1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034) .

HY-175333

*c-Met ligand-Linker* Conjugate 1**	Target Protein Ligand-Linker Conjugates c-Met/HGFR	Cancer
c-Met ligand-Linker Conjugate 1 is an *Target Protein Ligand-Linker* Conjugate** that incorporates a ligand for c-Met (HY-W425461) and a PROTAC linker (HY-151862), which recruits E3 ligases. c-Met ligand-Linker Conjugate 1 can be used for synthesis of PROTAC c-Met degrader-5 (HY-175320) .

HY-176791

*CDK12-Cyclin K Ligand-Linker* Conjugates 1**	Target Protein Ligand-Linker Conjugates CDK	Cancer
CDK12-Cyclin K Ligand-Linker Conjugates 1 is an *Target Protein Ligand-Linker* Conjugate** that incorporates a ligand for CDK12-Cyclin K (HY-176790) and a PROTAC linker (HY-W244922), which recruits E3 ligases. CDK12-Cyclin K Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC PP-C8 (HY-144691) .

HY-174409

*HDAC6 ligand-Linker* Conjugate 1**	Target Protein Ligand-Linker Conjugates HDAC	Cancer
HDAC6 ligand-linker conjugate 1 is a conjugate of HDAC6 ligand and linker, which can be used to synthesize PROTACs such as PROTAC HDAC6 degrader 5 (HY-174401) .

HY-125906

*VHL Ligand-Linker* Conjugates 15** E3 Ligase Ligand-linker Conjugates 56	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 15 incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs .

HY-128818

*cIAP1 Ligand-Linker* Conjugates 5** E3 ligase Ligand-linker Conjugates 39	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs .

HY-132943

*BRD4 ligand-Linker* Conjugate 1**	Target Protein Ligand-Linker Conjugates	Cancer
BRD4 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs.

HY-178311

*EGFR Ligand-Linker* Conjugates 4**	Target Protein Ligand-Linker Conjugates EGFR	Cancer
EGFR Ligand-Linker Conjugates 4 is a conjugate of the EGFR ligand (HY-178313) and the linker. EGFR Ligand-Linker Conjugates 4 can be used for synthesizing PROTAC EGFR degrader 16 (HY-178242) .

HY-44148

*FAK ligand-Linker* Conjugate 1**	Target Protein Ligand-Linker Conjugates	Cancer
FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation .

HY-175545

*CRBN ligand-Linker* Conjugate 1**	E3 Ligase Ligand-Linker Conjugates	Cancer
CRBN ligand-Linker Conjugate 1 is a CRBN ligand-linker conjugate that can be used for synthesis of TQ-3959 (HY-175541) .

HY-175528

*ALK ligand-Linker* Conjugate 1**	Target Protein Ligand-Linker Conjugates Anaplastic lymphoma kinase (ALK)	Cancer
ALK ligand-Linker Conjugate 1 is a ALK ligand-linker conjugate that can be used for synthesis of PROTAC ALK degrader-4 (HY-175527) .

HY-176872

*SMARCA2 Ligand-Linker* Conjugate-4**	Target Protein Ligand-Linker Conjugates SWI/SNF Complex	Cancer
SMARCA2 Ligand-Linker Conjugate-4 is a *Target Protein Ligand-Linker* Conjugate** that incorporates a ligand for SMARCA2 (HY-178414) and a PROTAC linker, which recruits E3 ligases. SMARCA2 Ligand-Linker Conjugate-4 can be used for synthesis of PROTAC SMARCA2 degrader-35 (HY-176871) .

HY-175450

*XIAP ligand-Linker* Conjugate 2**	E3 Ligase Ligand-Linker Conjugates IAP	Cancer
XIAP ligand-Linker Conjugate 2 is an *E3 ligase ligand-linker* conjugate** that incorporates the XIAP BIR2 ligand XB2M54 (HY-175348) and linker. XIAP ligand-Linker Conjugate 2 can be used for synthesis of PROTAC GNE-1567 (HY-175448) .

HY-173436

*E3 Ligase Ligand-linker* Conjugate 179**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 179 is an *E3 ubiquitinase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 179 can be used to synthesize JV8 (HY-173433) .

HY-176138

*E3 Ligase Ligand-linker* Conjugate 185**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 185 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 185 can be used to synthesize RP03707 (HY-176134) .

HY-168659

*E3 Ligase Ligand-linker* Conjugate 130**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 130 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 130 can be used to synthesize YJ1206 (HY-16855) .

HY-175444

*XIAP ligand-Linker* Conjugate 1**	E3 Ligase Ligand-Linker Conjugates IAP	Cancer
XIAP ligand-Linker Conjugate 1 is an *E3 ligase ligand-linker* conjugate** that incorporates the XIAP BIR2 ligand XB2M54 (HY-175348) and linker. XIAP ligand-Linker Conjugate 1 can be used for synthesis of PROTAC ERα Degrader-1 (HY-112098) .

HY-168871

*E3 Ligase Ligand-linker* Conjugate 161**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 161 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 161 can be used to synthesize Tamoxifen-PEG-Clozapine (HY-168869) .

HY-168701

*E3 Ligase Ligand-linker* Conjugate 149**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 149 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 149 can be used to synthesize Setidegrasib (HY-148273) .

HY-168866

*E3 Ligase Ligand-linker* Conjugate 160**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 160 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 160 can be used to synthesize FF2049 (HY-168863) .

HY-173563

*E3 Ligase Ligand-linker* Conjugate 181**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 181 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 185 can be used to synthesize MS115 (HY-173561) .

HY-172738

*E3 Ligase Ligand-linker* Conjugate 175**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 175 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 175 can be used to synthesize PROTAC SMARCA2 degrader-33 (HY-172735) .

HY-173358

*E3 Ligase Ligand-linker* Conjugate 174**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 174 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 174 can be used to synthesize TYD-68 (HY-173357) .

HY-173424

*E3 Ligase Ligand-linker* Conjugate 178**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 178 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 178 can be used to synthesize MS2133 (HY-173422) .

HY-176425

*E3 Ligase Ligand-linker* Conjugate 186**	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
E3 Ligase Ligand-linker Conjugate 186 is a CRBN *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 186 can be used to synthesize PROTAC SJ10542 (HY-145696) .

HY-173415

*E3 Ligase Ligand-linker* Conjugate 177**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 177 is an *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 177 can be used to synthesize STING PROTAC degrader ST9 .

HY-168295

*p62-ZZ Ligand-Linker* Conjugate 1**	E3 Ligase Ligand-Linker Conjugates Autophagy	Cancer
p62-ZZ Ligand-Linker Conjugate 1 is a p62-ZZ domain ligand-linker conjugate. p62-ZZ Ligand-Linker Conjugate 1 can be used to synthesize AUTOTAC VinclozolinM2-2204 (HY-161741) .

HY-176492

*E3 Ligase Ligand-linker* Conjugate 193**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 193 is an *E3 ligase ligand-linker* conjugate** that incorporates the VHL Ligase Ligand (HY-170353) and linker (HY-176491). E3 Ligase Ligand-linker Conjugate 193 can be used for synthesis of PROTAC pan-KRAS degrader-1 (HY-176489) .

HY-172949

*E3 Ligase Ligand-linker* Conjugate 187**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 187 is a CRBN *E3 ligase ligand-linker* conjugate*. E3 Ligase Ligand-linker* Conjugate 187 can be used to synthesize PROTAC SD-2301 (HY-172946) .

HY-130270

*AhR Ligand-Linker* Conjugates 1** E3 Ligase Ligand-linker Conjugates 57	E3 Ligase Ligand-Linker Conjugates	Cancer
AhR Ligand-Linker Conjugates 1 (E3 Ligase Ligand-Linker Conjugates 57) incorporates an IAP ligand for the E3 ubiquitin ligase, and a SNIPER linker. AhR Ligand-Linker Conjugates 1 can be used to design SNIPER .

HY-170854

*RET Ligand-Linker* Conjugate-1**	Target Protein Ligand-Linker Conjugates RET	Cancer
RET Ligand-Linker Conjugate-1 is the conjugate composed of a RET ligand and a linker. RET Ligand-Linker Conjugate-1 can be used for synthesis of QZ2135 (HY-170852) .

HY-169995

*E3 Ligase Ligand-linker* Conjugate 143**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 143 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of ACBI3 (HY-157228) .

HY-178862

*CDK9 ligand-Linker* Conjugate**	Target Protein Ligand-Linker Conjugates	Cancer
CDK9 ligand-Linker Conjugate is a synthesized CDK9 ligand-linker conjugate that can be used for synthesis of dCDK9-202 (HY-178861). dCDK9-202 is a potent CDK9 PROTAC degrader with anti-tumor activity .

HY-128822

*cIAP1 Ligand-Linker* Conjugates 13** E3 ligase Ligand-linker Conjugates 43	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 13 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 13 can be used to design SNIPERs .

HY-128813A

*cIAP1 Ligand-Linker* Conjugates 15 hydrochloride** E3 ligase Ligand-linker Conjugates 34 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 15 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 hydrochloride can be used to design SNIPERs .

HY-128815

*cIAP1 Ligand-Linker* Conjugates 14** E3 ligase Ligand-linker Conjugates 36	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 14 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 14 can be used to design SNIPERs .

HY-128820

*cIAP1 Ligand-Linker* Conjugates 1** E3 ligase Ligand-linker Conjugates 41	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 1 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 1 can be used to design SNIPERs .

HY-128819

*cIAP1 Ligand-Linker* Conjugates 3** E3 ligase Ligand-linker Conjugates 40	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 3 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 3 can be used to design SNIPERs .

HY-128826

*cIAP1 Ligand-Linker* Conjugates 10** E3 ligase Ligand-linker Conjugates 47	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 10 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 10 can be used to design SNIPERs .

HY-128812A

*cIAP1 Ligand-Linker* Conjugates 11 Hydrochloride** E3 ligase Ligand-linker Conjugates 33 Hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride can be used to design SNIPERs .

HY-128813

*cIAP1 Ligand-Linker* Conjugates 15** E3 ligase Ligand-linker Conjugates 34	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 15 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 can be used to design SNIPERs .

Cat. No.	Product Name	Type

HY-141658

Pomalidomide-PEG6-C2-COOH Pomalidomide-PEG6-COOH	Biochemical Assay Reagents
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide (HY-10984) based cereblon ligand and 6-unit PEG linker used in PROTAC technology .

HY-174925

Thalidomide-O-PEG3-COOH	Biochemical Assay Reagents
Thalidomide-O-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

Cat. No.	Product Name		Classification

HY-103601

(S,R,S)-AHPC-PEG4-N3 1 Publications Verification VH032-PEG4-N3; VHL Ligand-linker Conjugates 5; E3 ligase Ligand-linker Conjugates 4		Azide
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-linker Conjugates 8; E3 ligase Ligand-linker Conjugates 12		Azide
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL Ligand-linker Conjugates 9; E3 ligase Ligand-linker Conjugates 3		Azide
(S,R,S)-AHPC-PEG1-N3 (VH032-PEG1-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-174995

JQ-1-Azidopropylamine		Azide
JQ-1-Azidopropylamine is an *Target Protein Ligand-Linker* Conjugate** that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975) .

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification Cereblon Ligand-linker Conjugates 4; E3 ligase Ligand-linker Conjugates 18		Azide
Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker .

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon Ligand-linker Conjugates 13; E3 ligase Ligand-linker Conjugates 50		PROTAC Synthesis Azide
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 Ligand-linker Conjugates 1; E3 ligase Ligand-linker Conjugates 48		Azide
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-150251

SD-91 STAT3 degrader-2		PROTAC Synthesis
SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a K_i of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) .

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103599

(S,R,S)-AHPC-PEG2-N3 1 Publications Verification VH032-PEG2-N3; VHL Ligand-linker Conjugates 6; E3 ligase Ligand-linker Conjugates 13		Azide
(S,R,S)-AHPC-PEG2-N3 is a synthesized *E3 ligase ligand-linker* conjugate that incorporates the (S,R,S)-AHPC based VHL** ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-N3 can be used for the synthesis of PROTACs .

HY-126458

Thalidomide-O-PEG2-propargyl E3 ligase Ligand-linker Conjugates 32		Alkynes PROTAC Synthesis
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is an *E3 ligase ligand-linker* conjugate**. Thalidomide-O-PEG2-propargyl is also a click chemistry reagent containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules bearing an azide group .

HY-128767

VH032-PEG3-acetylene		Alkynes
VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology . VH032-PEG3-acetylene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-140844

Thalidomide-O-PEG4-azide		Azide
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137538

Pomalidomide-PEG3-azide		Azide
Pomalidomide-PEG3-azide is a synthesized *E3 ligase ligand-linker* conjugate** that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130652

Pomalidomide 4'-PEG3-azide		Azide PROTAC Synthesis
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132208

Pomalidomide 4'-PEG2-azide		Azide
Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137537

Pomalidomide-PEG2-azide		Azide
Pomalidomide-PEG2-azide is a synthesized *E3 ligase ligand-linker* conjugate** that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-148556

Thalidomide-O-C6-azide		Azide
Thalidomide-O-C6-azide is a synthesized *E3 ligase ligand-linker* conjugate** that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology . Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-175860

*KRAS G12D ligand-Linker* Conjugate 2**		Alkynes
KRAS G12D ligand-Linker Conjugate 2 is a conjugate of the KRAS (G12D) ligand (HY-175859) and the linker (HY-168698). KRAS G12D ligand-Linker Conjugate 2 can be used for synthesizing PROTAC KRAS (G12D) degrader ASP-3082 (HY-157505) .

HY-130654

(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3		Azide
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized *E3 ligase ligand-linker* conjugate** that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM . (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W457949

Pomalidomide 4'-alkylC4-azide		Azide
Pomalidomide 4'-alkylC4-azide (Compound 2) is an azide compound containing a MIDI group and is one of the compounds used to construct a library of MIDI azide compounds. Pomalidomide 4'-alkylC4-azide is an E3 ligase ligand and linker conjugate (E3 Ligase Ligand-Linker Conjugate). Pomalidomide 4'-alkylC4-azide can be used to develop research on PROTAC degraders .

HY-175268

*PXR ligand-Linker* Conjugate 1**		Azide
PXR ligand-Linker Conjugate 1 is a conjugate of PXR ligand and linker, which can be used to synthesize PROTAC MI1013 (HY-175266) .

HY-W190931

Thalidomide-O-PEG5-alkyne		Alkynes
Thalidomide-O-PEG5-alkyne is an *E3 ligase ligand-linker* conjugate** containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-139332

Pomalidomide 4'-PEG6-azide		Azide
Pomalidomide 4'-PEG6-azide (compound 33e) is the *E3 ligase ligand-linker* conjugate** used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-159801

*E3 Ligase Ligand-linker* Conjugate 122**		Azide
E3 Ligase Ligand-linker Conjugate 122 (Compound 2c) is a conjugation of the E3 ligase ligand and the linker, and can be used for synthesis of PROTAC degrader NR-11c (HY-159798) .

HY-168458

*RNA recruiter-linker* 1**		Alkynes
RNA recruiter-linker 1 is the RNA ligand-linker part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNA recruiter-linker 1 can be utilized in the synthesis of RIBOTAC .

HY-174473

Thalidomide-NH-alkynes		Alkynes
Thalidomide-NH-alkynes is a synthesized *E3 ligase ligand-linker* conjugate** that can be used for synthesis of PROTAC HDAC degrader-2 (HY-174444) .

HY-161832

(S,R,S)-Me-AHPC-amide-C3-alkyne		Alkynes
(S,R,S)-Me-AHPC-amide-C3-alkyne is an E3 ligase ligand-linker conjugate used for the synthesis of JWZ-5-13 (HY-161828) .

HY-159165

Pomalidomide-cyclopentane-amide-Alkyne		Alkynes
Pomalidomide-cyclopentane-amide-Alkyne is an *E3 ligase ligand-linker* conjugate** that incorporates the Pomalidomide (HY-10984) and the linker cyclopentane-amide-Alkyne. Pomalidomide-cyclopentane-amide-Alkyne is used to form PROTACs, such as RGB110 (HY-159087) .

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-140055

Thalidomide-PEG4-Propargyl		Alkynes
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (*E3 Ligase Ligand-Linker* Conjugates) for the synthesis of PROTAC**s .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (*E3 Ligase Ligand-Linker* Conjugates**) for the synthesis of PROTACs .

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (*E3 Ligase Ligand-Linker* Conjugates) for the synthesis of PROTACs** .

HY-179603

(S,R,S)-AHPC-PEG3-azide		Azide
E3 Ligase Ligand-linker Conjugate 220 is an *E3 ligase ligand-linker* conjugat**e, can be used for synthesis of PROTAC 11β-HSD1 Degrader 1 (HY-179602) .

HY-162948

(S,R,S)-AHPC-PEG2-C5-N3		Azide
(S,R,S)-AHPC-PEG2-C5-N3 is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-C5-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-W998284

Thalidomide-O-C2-alkyne		Alkynes
Thalidomide-O-C2-alkyne is an *E3 ligase ligand-linker* conjugate** containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-180902

Pomalidomide-C11-azide		Azide
Pomalidomide-C11-azide is a synthetic E3 ligase ligand-linker conjugate, which can be used for the synthesis of PROTAC BRD3 degrader-1 (HY-180889) .

HY-163964

Lenalidomide-C3-PEG3-N3		Azide
Lenalidomide-C3-PEG3-N3 is an E3 Ligase Ligand-Linker Conjugate. Lenalidomide-C3-PEG3-N3 can be used to synthesize L18I (HY-163962) .

HY-175948

Lenalidomide-CO-C3-NH-alkynes		PROTAC Synthesis Alkynes
Lenalidomide-CO-C3-NH-alkynes is an *E3 ligase ligand-linker* conjugate** comprising Lenalidomide (HY-A0003) and a linker. Acepromazine-1-piperazinepropanamine dihydrochloride can be conjugated to a target protein ligand to form a PROTAC molecule—for instance, the PROTAC EGFR degrader 7 (HY-147858) .

HY-178067

Phthalimidinoglutarimide-5-piperazine-COC2-alkynes		Alkynes
Phthalimidinoglutarimide-5-piperazine-COC2-alkynes is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC BCL-xL/BCL-w Degrader 1 (HY-178066). PROTAC BCL-xL/BCL-w Degrader 1 is a potent BCL-xL/BCL-w PROTAC degrader with anti-cancer activity .

HY-181356

(S,R,S,R)-AHPC-Me-CO-C7-N3		Azide
(S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S,R)-AHPC-Me based VHL ligand and a linker used in PROTAC technology. (S,R,S,R)-AHPC-Me-CO-C7-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-28 (HY-181355) .

HY-182978

Pomalidomide-C3-O-C4-O-C3-NH2		PROTAC Synthesis
Pomalidomide-C3-O-C4-O-C3-NH2 is an E3 ligase ligand-linker conjugate that contains Pomalidomide (HY-10984). Pomalidomide-C3-O-C4-O-C3-NH2 can be used for the synthesis of PROTACs targeting glycogen synthase kinase 3β (GSK-3β), such as PROTAC GSK-3β Degrader-1 (HY-149845) .

HY-181358

(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3		Azide
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-29 (HY-181357) .

HY-180924

(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3		Azide
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-30 (HY-181359) .

Cat. No.	Product Name		Classification

HY-174863

Pomalidomide-C2-PEG-NHCO-C2-COOH		Pegylated Lipids
Pomalidomide-C2-PEG-NHCO-C2-COOH is a conjugate of the CRBN ligand (HY-10984) and the linker (*E3 Ligase Ligand-Linker* Conjugate**). Pomalidomide-C2-PEG-NHCO-C2-COOH can be used for synthesizing PROTAC ASK1 degrader dASK1 (HY-174862) .

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