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Cat. No.: HY-173436

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E3 Ligase Ligand-linker Conjugate 179

E3 Ligase Ligand-linker Conjugate 179 is an E3 ubiquitinase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 179 can be used to synthesize JV8 (HY-173433).

For research use only. We do not sell to patients.

Formula: C₃₃H₄₈F₃N₅O₉S
Molecular Weight:747.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

E3 Ligase Ligand-linker Conjugate 179 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

E3 Ligase Ligand-linker Conjugate 179 is an E3 ubiquitinase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 179 can be used to synthesize JV8 (HY-173433)^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

Molecular Weight 747.82
Formula C₃₃H₄₈F₃N₅O₉S
SMILES

[NH3+]CCOCCOCCOCC(N[C@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O.FC(F)(C([O-])=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li T, et al. Non-invasive in vivo monitoring of PROTAC-mediated protein degradation using an environment-sensitive reporter. Nat Commun. 2025 Feb 22;16(1):1892. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

E3 Ligase Ligand-linker Conjugate 179

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E3 Ligase Ligand-linker Conjugate 179

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E3 Ligase Ligand-linker Conjugate 179 Related Classifications

HY-173436 Related Classifications

Bioz

Keywords

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