(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-29 (HY-181357).
For research use only. We do not sell to patients.
- CAS No.: 2977227-58-8
- Formula: C36H40Cl2N8O6
- Molecular Weight:751.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 2977227-58-8
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Molecular Weight 751.66
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Formula C36H40Cl2N8O6
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SMILES
O=C(N1CC(N(CC1)CC(NCCOCCN=[N+]=[N-])=O)=O)N2[C@@H](C3=CC=C(C=C3)Cl)[C@@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)OC)OC(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 Related Classifications
HY-181358 Related Classifications
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