2977227-58-8
2977227-58-8
Chemical Structure
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3
- CAS No.: 2977227-58-8
- Formula:C36H40Cl2N8O6
- Molecular Weight:751.66
InChIKey: RBFOAKCBENSFOT-NOCHOARKSA-N
SMILES: O=C(N1CC(N(CC1)CC(NCCOCCN=[N+]=[N-])=O)=O)N2[C@@H](C3=CC=C(C=C3)Cl)[C@@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)OC)OC(C)C
Biological Activity: (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-29 (HY-181357)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 | (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-29 (HY-181357). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
